Stimulation of reactive oxygen species production by an antidepressant visible light source

Dan A. Oren; Dennis S. Charney; Ronit Lavie; Michael Sinyakov; Rachel Lubart

doi:10.1016/s0006-3223(00)01106-9

Stimulation of reactive oxygen species production by an antidepressant visible light source

Dan A. Oren, Dennis S. Charney, Ronit Lavie, Michael Sinyakov, Rachel Lubart

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background: The mechanism by which visible light stimulates chronobiological phase-shifting or antidepressant effects in humans is unknown. Methods: Normal human NIH/3T3 nonpigmented fibroblasts were irradiated with a visible light source (SunRay) used in the treatment of winter seasonal depression. Electron spin resonance was assessed before and after 10 min of illumination at 2 mW/cm² (illuminance of 3700 lux), with and without the presence of 5 μL of 0.0214 mg/mL vitamin C. Results: The fibroblasts showed evidence of production of reactive oxygen species after 10 min of irradiation. Conclusions: These in vitro data establish that an antidepressant source of visible light is capable of inducing the production of reactive oxygen species in skin. Such species may participate in signal transduction pathways leading to mood changes.

Original language	English
Pages (from-to)	464-467
Number of pages	4
Journal	Biological Psychiatry
Volume	49
Issue number	5
DOIs	https://doi.org/10.1016/s0006-3223(00)01106-9
State	Published - 1 Mar 2001

Bibliographical note

Funding Information:
Supported by a Career Development Award from the U.S. Department of Veterans Affairs (DAO).

Funding

Supported by a Career Development Award from the U.S. Department of Veterans Affairs (DAO).

Funders	Funder number
DAO
U.S. Department of Veterans Affairs

Keywords

Depression
Fibroblasts
Light
Light box
Reactive oxygen species
Winter

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10.1016/s0006-3223(00)01106-9

Cite this

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title = "Stimulation of reactive oxygen species production by an antidepressant visible light source",

abstract = "Background: The mechanism by which visible light stimulates chronobiological phase-shifting or antidepressant effects in humans is unknown. Methods: Normal human NIH/3T3 nonpigmented fibroblasts were irradiated with a visible light source (SunRay) used in the treatment of winter seasonal depression. Electron spin resonance was assessed before and after 10 min of illumination at 2 mW/cm2 (illuminance of 3700 lux), with and without the presence of 5 μL of 0.0214 mg/mL vitamin C. Results: The fibroblasts showed evidence of production of reactive oxygen species after 10 min of irradiation. Conclusions: These in vitro data establish that an antidepressant source of visible light is capable of inducing the production of reactive oxygen species in skin. Such species may participate in signal transduction pathways leading to mood changes.",

keywords = "Depression, Fibroblasts, Light, Light box, Reactive oxygen species, Winter",

author = "Oren, {Dan A.} and Charney, {Dennis S.} and Ronit Lavie and Michael Sinyakov and Rachel Lubart",

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AU - Oren, Dan A.

AU - Charney, Dennis S.

AU - Lavie, Ronit

AU - Sinyakov, Michael

AU - Lubart, Rachel

N1 - Funding Information: Supported by a Career Development Award from the U.S. Department of Veterans Affairs (DAO).

PY - 2001/3/1

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N2 - Background: The mechanism by which visible light stimulates chronobiological phase-shifting or antidepressant effects in humans is unknown. Methods: Normal human NIH/3T3 nonpigmented fibroblasts were irradiated with a visible light source (SunRay) used in the treatment of winter seasonal depression. Electron spin resonance was assessed before and after 10 min of illumination at 2 mW/cm2 (illuminance of 3700 lux), with and without the presence of 5 μL of 0.0214 mg/mL vitamin C. Results: The fibroblasts showed evidence of production of reactive oxygen species after 10 min of irradiation. Conclusions: These in vitro data establish that an antidepressant source of visible light is capable of inducing the production of reactive oxygen species in skin. Such species may participate in signal transduction pathways leading to mood changes.

AB - Background: The mechanism by which visible light stimulates chronobiological phase-shifting or antidepressant effects in humans is unknown. Methods: Normal human NIH/3T3 nonpigmented fibroblasts were irradiated with a visible light source (SunRay) used in the treatment of winter seasonal depression. Electron spin resonance was assessed before and after 10 min of illumination at 2 mW/cm2 (illuminance of 3700 lux), with and without the presence of 5 μL of 0.0214 mg/mL vitamin C. Results: The fibroblasts showed evidence of production of reactive oxygen species after 10 min of irradiation. Conclusions: These in vitro data establish that an antidepressant source of visible light is capable of inducing the production of reactive oxygen species in skin. Such species may participate in signal transduction pathways leading to mood changes.

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KW - Fibroblasts

KW - Light

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KW - Reactive oxygen species

KW - Winter

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Stimulation of reactive oxygen species production by an antidepressant visible light source

Abstract

Bibliographical note

Funding

Keywords

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