Stimulating the development of drug treatments to improve cognition in schizophrenia

Michael F. Green

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

64 Scopus citations


Cognitive impairment in schizophrenia is a core feature of the illness (i.e., not a result of clinical symptoms or drug treatments) that is related to the daily functioning of patients. Because schizophrenia is associated with poor community functioning, there is considerable interest in finding treatments to improve cognition in schizophrenia in the hopes that such improvement will yield functional benefits. Before the U.S. Food and Drug Administration could consider granting approval to any new drug for improving cognition in schizophrenia, it was first necessary to achieve consensus on the measurements and methods that would be used in clinical trials, as well as neuropharmacological targets. The U.S. National Institute of Mental Health launched an initiative to help address these obstacles to drug approval (MATRICS). This initiative has generated several additional follow-up initiatives including a clinical trial network and consensus projects for other clinical targets, such as negative symptoms. This review describes how an area that was primarily of academic interest (cognition in schizophrenia) became a focus of public health concerns and drug-development policy.

Original languageEnglish
Title of host publicationAnnual Review of Clinical Psychology
EditorsSusan Nolen-Hoeksema
Number of pages22
StatePublished - 2007
Externally publishedYes

Publication series

NameAnnual Review of Clinical Psychology
ISSN (Print)1548-5943


  • FDA
  • NIMH
  • Neurocognition


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