Steroid phosphate esters

Milon Sprecher, Ronald Breslow, Rachel Philosof-Oppenheimer, Eliram Chavet

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Four phosphorylation procedures were used in the preparation and characterization of sundry steroid phosphate and phosphonate esters, as well as some P1,P2-disteroid pyrophosphates. An attempt to prepare cholest-3,5- dien-3-yl dialkyl phosphate by a vinylogous Perkow reaction from 6- bromocholest-4-en-3-one yielded only dienenones. As a model for P1,P2- disteroid pyrophosphate (and steroid phosphate) behavior in solution, the neutral crystalline complex 2,2'-bipyridine zinc P1,P2-bis(1-n- dodecyl)pyrophosphate was prepared and characterized.

Original languageEnglish
Pages (from-to)5465-5482
Number of pages18
JournalTetrahedron
Volume55
Issue number17
DOIs
StatePublished - 23 Apr 1999

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