TY - JOUR
T1 - Stereoisomeric effect on in vitro drug release from injectable poly(lactic acid co castor oil) polyesters
AU - Sokolsky-Papkov, Marina
AU - Domb, Abraham J.
PY - 2008/6
Y1 - 2008/6
N2 - A systematic study on the influence of lactic acid (LA) conformation on polyester properties, degradation, and drug release profiles is reported. Copolyesters based on L- or DL-LA and castor oil (CO) (triglyceride of ricinoleic acid (RA)) were synthesized by melt condensation. Two feed ratios of LA to CO were used. Copolymers with feed ratio of 60:40 and 50:50 LA to CO were synthesized. P(LA/CO)s 60:40 and 50:50 had weight average molecular weights (Mw) of 4700 and 3700, respectively. All polymers are viscous liquids at room temperature. Copolymer composition and LA conformation had direct effect on polymer properties, degradation rate, and drug release profile. Increase in CO content (hydrophobisity) decreased the degradation and release rates of the polymers. Effect of sample size was also different for all polymers. Choosing polymer composition and LA conformation it is possible to choose desired release profile for the tested drug.
AB - A systematic study on the influence of lactic acid (LA) conformation on polyester properties, degradation, and drug release profiles is reported. Copolyesters based on L- or DL-LA and castor oil (CO) (triglyceride of ricinoleic acid (RA)) were synthesized by melt condensation. Two feed ratios of LA to CO were used. Copolymers with feed ratio of 60:40 and 50:50 LA to CO were synthesized. P(LA/CO)s 60:40 and 50:50 had weight average molecular weights (Mw) of 4700 and 3700, respectively. All polymers are viscous liquids at room temperature. Copolymer composition and LA conformation had direct effect on polymer properties, degradation rate, and drug release profile. Increase in CO content (hydrophobisity) decreased the degradation and release rates of the polymers. Effect of sample size was also different for all polymers. Choosing polymer composition and LA conformation it is possible to choose desired release profile for the tested drug.
KW - Degradation
KW - Drug delivery systems
KW - Polyesters
KW - Structure-property relations
UR - http://www.scopus.com/inward/record.url?scp=47149112438&partnerID=8YFLogxK
U2 - 10.1002/pat.1140
DO - 10.1002/pat.1140
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:47149112438
SN - 1042-7147
VL - 19
SP - 671
EP - 679
JO - Polymers for Advanced Technologies
JF - Polymers for Advanced Technologies
IS - 6
ER -