Stereocomplexes of triblock poly(lactide- PEG2000-lactide) as carrier of drugs

Ashgan Bishara, Hans R. Kricheldorf, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Triblock copolymers of poly(lactide)-poly(ethylene-grycol)-poly(lactide) {PLA-PEG2000-PLA) were synthesized by ring-opening polymerization of lactide and PEG2000 diol as co-catalyst. Stereocomplexes with particle sizes ranging from nanometers to microns were obtained by mixing acetonitrite solutions of pairs of enantiomeric homopoly(lactide) and the triblock copolymers. The stereocomplexes exhibited higher crystalline melting temperatures than the optically pure polymers. The ratio of PLA terminals in the copolymers had a significant effect on their stereocomplex degradation and drug release. These stereocomplexes were used for the encapsulation of dexamethasone for controlled release applications. Dexamethasone phosphate loading capacity, in vitro release, degradation and stability of polymers and formulation were investigated for one month. An increase in the dexamethsone phosphate content in the stereocomplex or a decrease in the PLA ratio in the copolymer resulted in a faster release of drug and polymer degradation.

Original languageEnglish
Pages (from-to)17-30
Number of pages14
JournalMacromolecular Symposia
Volume225
DOIs
StatePublished - May 2005
Externally publishedYes

Keywords

  • Controlled release
  • Degradation
  • Dexamethasone phosphate
  • Poly(ethylene glycol)
  • Polylactide
  • Stereocomplex

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