TY - JOUR
T1 - Stereocomplexes, based on biodegradable polymers and bioactive macromolecules
AU - Slager, Joram
AU - Gladnikoff, Micha
AU - Domb, Abraham J.
PY - 2001
Y1 - 2001
N2 - Stereocomplexation between two enantiomeric polymers such as D-PLA and L-PLA have been described in the literature. No reports up till now have been published on the complexation between two non-identical complementary polymers. Stereocomplexes between poly(lactide) enantiomers and a representative peptide, LHRH, was investigated. The complex was shown to be of physical character (NMR, IR, X-ray) without any irriversibility. DSC-scans show an additional signal related to the second (β-) and thermally less stable form of isotactic PLA. A linear correlation was found between the amount of peptide added to D-PLA and the measured enthalpies. An overall decrease in crystallinity was noticed. Less than 5% of the total amount of peptide was found free in solution after complexation with PLA. A controlled release of peptide was measured for about 3 months in-vitro. In-vivo similar results were obtained as earlier reported for a commercial available controlled release device containing LHRH
AB - Stereocomplexation between two enantiomeric polymers such as D-PLA and L-PLA have been described in the literature. No reports up till now have been published on the complexation between two non-identical complementary polymers. Stereocomplexes between poly(lactide) enantiomers and a representative peptide, LHRH, was investigated. The complex was shown to be of physical character (NMR, IR, X-ray) without any irriversibility. DSC-scans show an additional signal related to the second (β-) and thermally less stable form of isotactic PLA. A linear correlation was found between the amount of peptide added to D-PLA and the measured enthalpies. An overall decrease in crystallinity was noticed. Less than 5% of the total amount of peptide was found free in solution after complexation with PLA. A controlled release of peptide was measured for about 3 months in-vitro. In-vivo similar results were obtained as earlier reported for a commercial available controlled release device containing LHRH
UR - http://www.scopus.com/inward/record.url?scp=70449501700&partnerID=8YFLogxK
U2 - 10.1002/1521-3900(200110)175:1<105::AID-MASY105>3.0.CO;2-C
DO - 10.1002/1521-3900(200110)175:1<105::AID-MASY105>3.0.CO;2-C
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AN - SCOPUS:70449501700
SN - 1022-1360
VL - 175
SP - 105
EP - 116
JO - Macromolecular Symposia
JF - Macromolecular Symposia
ER -