Stereocomplexes, based on biodegradable polymers and bioactive macromolecules

Joram Slager, Micha Gladnikoff, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Stereocomplexation between two enantiomeric polymers such as D-PLA and L-PLA have been described in the literature. No reports up till now have been published on the complexation between two non-identical complementary polymers. Stereocomplexes between poly(lactide) enantiomers and a representative peptide, LHRH, was investigated. The complex was shown to be of physical character (NMR, IR, X-ray) without any irriversibility. DSC-scans show an additional signal related to the second (β-) and thermally less stable form of isotactic PLA. A linear correlation was found between the amount of peptide added to D-PLA and the measured enthalpies. An overall decrease in crystallinity was noticed. Less than 5% of the total amount of peptide was found free in solution after complexation with PLA. A controlled release of peptide was measured for about 3 months in-vitro. In-vivo similar results were obtained as earlier reported for a commercial available controlled release device containing LHRH

Original languageEnglish
Pages (from-to)105-116
Number of pages12
JournalMacromolecular Symposia
StatePublished - 2001
Externally publishedYes


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