Stepwise Versus Concerted Mechanisms in General-Base Catalysis by Serine Proteases

Keyphrases

• Serine Protease 100%
• Acid-base Catalysis 100%
• Concerted Mechanism 100%
• Catalytic Triad 66%
• Active Sites 33%
• Michaelis Complex 33%
• GlpG 33%
• Water Exposure 33%
• Tetrahedral Complexes 33%
• Catalytic Residues 33%
• Covalent Inhibitor 33%
• Chymotrypsin 33%
• Proton Transfer 33%
• Reduced Water 33%
• VS Method 33%
• Ser-His 33%
• Stepwise Mechanism 33%
• Catalytic Steps 33%
• Rhomboid 33%
• Trifluoromethane 33%

Chemistry

• Base Catalysis 100%
• Serine 100%
• pKa 66%
• Proton Transfer 33%
• His-Ser 33%
• Asp-His 33%
• Ser-His 33%