Statistical physics and Alzheimer's disease

H. Eugene Stanley; Sergey V. Buldyrev; Luis Cruz; Teresa Gomez-Isla; Shlomo Havlin; Bradley T. Hyman; Roger Knowles; Brigita Urbanc; Claire Wyart

doi:10.1016/S0378-4371(97)00548-7

Statistical physics and Alzheimer's disease

H. Eugene Stanley, Sergey V. Buldyrev, Luis Cruz, Teresa Gomez-Isla, Shlomo Havlin, Bradley T. Hyman, Roger Knowles, Brigita Urbanc, Claire Wyart

Department of Physics

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12 Scopus citations

Abstract

We discuss the possible utility of statistical physics in elucidating some of the puzzling phenomena that seem to occur in the brains of patients affected with Alzheimer's disease. Further, we report three specific results from this approach: (i) The size distribution of senile plaques appears to be log-normal, (ii) We develop a model for growth of senile plaques that is characterized by both aggregation and disaggregation, and (iii) We quantify neuron architecture and find quantitative evidence for the existence of microcolumns positioned at right angles to the known lamina.

Original language	English
Pages (from-to)	460-471
Number of pages	12
Journal	Physica A: Statistical Mechanics and its Applications
Volume	249
Issue number	1-4
DOIs	https://doi.org/10.1016/S0378-4371(97)00548-7
State	Published - 2 Jan 1998

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health Grant AG08487 and by generous gifts from the Walters Family Foundation. We also thank the Massachusetts Alzheimer Disease Research Center Brain Bank (NIA AG05134, Dr. E.T. Hedley-Whyte, director) for tissue samples.

Funding

This work was supported by National Institutes of Health Grant AG08487 and by generous gifts from the Walters Family Foundation. We also thank the Massachusetts Alzheimer Disease Research Center Brain Bank (NIA AG05134, Dr. E.T. Hedley-Whyte, director) for tissue samples.

Funders	Funder number
Walters Family Foundation
National Institutes of Health	AG08487

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abstract = "We discuss the possible utility of statistical physics in elucidating some of the puzzling phenomena that seem to occur in the brains of patients affected with Alzheimer's disease. Further, we report three specific results from this approach: (i) The size distribution of senile plaques appears to be log-normal, (ii) We develop a model for growth of senile plaques that is characterized by both aggregation and disaggregation, and (iii) We quantify neuron architecture and find quantitative evidence for the existence of microcolumns positioned at right angles to the known lamina.",

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AU - Knowles, Roger

AU - Urbanc, Brigita

AU - Wyart, Claire

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Statistical physics and Alzheimer's disease

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