Statistical analysis of animal cancer chemoprevention experiments

L. S. Freedman, D. N. Midthune, C. C. Brown, V. Steele, G. J. Kelloff

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We explore the use of a statistical model proposed by Kokoska for the analysis of animal cancer chemoprevention experiments. We show, using an example, that the results derived from the method can be sensitive to the parametric forms of the distributions that are assumed, particularly to the distribution of the number of tumors per animal. We propose goodness-of-fit tests to aid in the choice of the distributions.

Original languageEnglish
Pages (from-to)259-268
Number of pages10
Issue number1
StatePublished - 1993
Externally publishedYes


  • Carcinogen
  • Goodness of fit
  • Negative binomial
  • Poisson
  • Survival analysis
  • Tumor initiation
  • Tumor promotion


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