TY - JOUR
T1 - Statins in nonalcoholic fatty liver disease and steatohepatitis
T2 - Updated review
AU - Nseir, William
AU - Mahamid, Mahmud
PY - 2013/3
Y1 - 2013/3
N2 - Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that refers to the presence of hepatic steatosis without significant intake of alcohol. NAFLD is an asymptomatic disease that can progress to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. The most common cause of mortality in patients with NAFLD or NASH is cardiovascular disease (CVD). Currently, the treatment of NAFLD focuses on gradual weight loss and life style modifications. However, multifactorial treatment of NAFLD or NASH risk factors may be needed to reduce the likelihood of these patients developing CVD. This review discusses the mechanisms that link hyperlipidemia and NAFLD. In addition, the review focuses on the safety and efficacy of statins in patientswith NAFLD orNASH, and their effect on the extent of hepatic steatosis and fibrosis based on human studies.
AB - Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that refers to the presence of hepatic steatosis without significant intake of alcohol. NAFLD is an asymptomatic disease that can progress to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. The most common cause of mortality in patients with NAFLD or NASH is cardiovascular disease (CVD). Currently, the treatment of NAFLD focuses on gradual weight loss and life style modifications. However, multifactorial treatment of NAFLD or NASH risk factors may be needed to reduce the likelihood of these patients developing CVD. This review discusses the mechanisms that link hyperlipidemia and NAFLD. In addition, the review focuses on the safety and efficacy of statins in patientswith NAFLD orNASH, and their effect on the extent of hepatic steatosis and fibrosis based on human studies.
KW - Hyperlipidemia
KW - Metabolic syndrome
KW - Statins
KW - Steatohepatitis
UR - http://www.scopus.com/inward/record.url?scp=84872196813&partnerID=8YFLogxK
U2 - 10.1007/s11883-012-0305-5
DO - 10.1007/s11883-012-0305-5
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C2 - 23328905
AN - SCOPUS:84872196813
SN - 1523-3804
VL - 15
JO - Current Atherosclerosis Reports
JF - Current Atherosclerosis Reports
IS - 3
M1 - 305
ER -
