TY - JOUR
T1 - Statin Use Over 65 Years of Age and All-Cause Mortality
T2 - A 10-Year Follow-Up of 19 518 People
AU - Eilat-Tsanani, Sophia
AU - Mor, Elad
AU - Schonmann, Yochai
N1 - Publisher Copyright:
© 2019 The American Geriatrics Society
PY - 2019/10/1
Y1 - 2019/10/1
N2 - OBJECTIVES: As life expectancy continues to rise, the burden of cardiovascular disease among older people is expected to increase, making cardiovascular prevention in older people an issue of growing interest and public health importance. We aimed to explore the long-term effects of adherence to statins on mortality and cardiovascular morbidity among older adults. DESIGN: A historical population-based cohort study using routinely collected data. SETTING: Clalit Health Services Northern District. PARTICIPANTS: We followed members of Clalit Health Services aged 65 years or older who were eligible for primary cardiovascular prevention for a period of 10 years. MEASUREMENTS: We fitted Cox regression models to assess the association between the adherence to statin therapy and all-cause mortality and cardiovascular morbidity, adjusting for cardiovascular risk factors and associated morbidity as time-updated variables. RESULTS: The analysis included 19 518 older adults followed during 10 years (median = 9.7 y). All-cause mortality rates were 34% lower among those who had adhered to statin treatment, compared with those who had not (hazard ratio [HR] =.66; 95% confidence interval [CI] =.56-.79). Adherence to statins was also associated with fewer atherosclerotic cardiovascular disease events (HR =.80; 95% CI =.71-.81). The benefit of statin use did not diminish among beyond age 75 and was evident for both women and men. CONCLUSION: Adherence to statins may be associated with reduced mortality and cardiovascular morbidity among older adults, regardless of age and sex. J Am Geriatr Soc 67:2038–2044, 2019.
AB - OBJECTIVES: As life expectancy continues to rise, the burden of cardiovascular disease among older people is expected to increase, making cardiovascular prevention in older people an issue of growing interest and public health importance. We aimed to explore the long-term effects of adherence to statins on mortality and cardiovascular morbidity among older adults. DESIGN: A historical population-based cohort study using routinely collected data. SETTING: Clalit Health Services Northern District. PARTICIPANTS: We followed members of Clalit Health Services aged 65 years or older who were eligible for primary cardiovascular prevention for a period of 10 years. MEASUREMENTS: We fitted Cox regression models to assess the association between the adherence to statin therapy and all-cause mortality and cardiovascular morbidity, adjusting for cardiovascular risk factors and associated morbidity as time-updated variables. RESULTS: The analysis included 19 518 older adults followed during 10 years (median = 9.7 y). All-cause mortality rates were 34% lower among those who had adhered to statin treatment, compared with those who had not (hazard ratio [HR] =.66; 95% confidence interval [CI] =.56-.79). Adherence to statins was also associated with fewer atherosclerotic cardiovascular disease events (HR =.80; 95% CI =.71-.81). The benefit of statin use did not diminish among beyond age 75 and was evident for both women and men. CONCLUSION: Adherence to statins may be associated with reduced mortality and cardiovascular morbidity among older adults, regardless of age and sex. J Am Geriatr Soc 67:2038–2044, 2019.
KW - all-cause mortality
KW - cardiovascular events
KW - hypercholesterolemia
KW - older adults
KW - primary prevention
UR - http://www.scopus.com/inward/record.url?scp=85068734809&partnerID=8YFLogxK
U2 - 10.1111/jgs.16060
DO - 10.1111/jgs.16060
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C2 - 31287932
AN - SCOPUS:85068734809
SN - 0002-8614
VL - 67
SP - 2038
EP - 2044
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 10
ER -