Starch functionalized biodegradable semi-IPN as a pH-tunable controlled release platform for memantine

Sayan Ganguly, Tushar Maity, Subhadip Mondal, Poushali Das, Narayan C. Das

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Sequentially prepared semi-interpenetrating polymer network (semi-IPN) has been developed here via Michael type addition of acrylic acid (AA) and 2-acrylamido-2-methylpropane sulfonic acid (AMPS) on to starch. The semi-IPN hydrogel have proficiency in fast water imbibition towards gel network and swelling tunable character with pH alteration in ambient condition. The synthesized gel has been characterized by Fourier transformed infrared spectroscopy (FTIR) to confirm Michael type grafting of monomers on to starch. The surface morphology, observed from Scanning Electron Microscopy (SEM) exhibited corrugated rough surface on hydrogel which enhances the fast water uptake feature by anomalous Fickian case II diffusion mechanism. Grafting reaction also improves its thermal stability which has been confirmed by thermogravimetric analysis (TGA). Biodegradation study with hen egg lysozyme medium reveals the accelerated enzymatic scission of the starch backbone and progressive mass loss. Degradation of the hydrogel around 60% of its primary mass has been observed within 7 days. The physicochemical characterizations of this hydrogel suggest this as a promising pH-tunable, biodegradable candidate for control drug delivery vehicle.

Original languageEnglish
Pages (from-to)185-198
Number of pages14
JournalInternational Journal of Biological Macromolecules
StatePublished - 1 Feb 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.


  • Biodegradation
  • Corrugated rough surface
  • Drug delivery
  • Semi interpenetrating polymer network
  • Water imbibition
  • pH-tunable


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