Stable polyanhydride synthesized from sebacic acid and ricinoleic acid

Moran Haim-Zada, Arijit Basu, Tal Hagigit, Ron Schlinger, Michael Grishko, Alexander Kraminsky, Ezra Hanuka, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Poly(anhydride) are unstable and prone to hydrolytic degradation and depolymerisation via anhydride interchange. They are stored at − 20 °C, packed under inert atmosphere until use. We synthesized a new poly(anhydride) from ricinoleic (RA) and sebacic (SA) acid with alternating ester-anhydride structure that is stable at 25 °C for over 18 months. The copolymer is also stable in chloroform solution and under γ-irradiation. The polymer hydrolyses through anhydride cleavage lasting ~ 7 days to form oligoesters, which are stable for > 30 days. The release of gentamycin from the synthesized alternate polymer matrix is sustained compared to the random copolymer.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalJournal of Controlled Release
StatePublished - 10 Jul 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.


  • Alternating polymers
  • Anhydride interchange
  • Drug release
  • Poly anhydrides
  • Ricinoleic acid
  • Sebacic acid


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