Stability of visual masking performance in recent-onset schizophrenia: An 18-month longitudinal study

Junghee Lee, Keith H. Nuechterlein, Kenneth L. Subotnik, Catherine A. Sugar, Joseph Ventura, Denise Gretchen-Doorly, Kimberly Kelly, Michael F. Green

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Visual masking deficit in schizophrenia has been suggested to be a potential vulnerability marker for schizophrenia. An important characteristic of a vulnerability marker is stability over time, but relatively little is known about the longitudinal course of masking performance of schizophrenia patients. In this study, we examined the stability of visual masking performance in recent-onset schizophrenia patients over an 18-month period. We administered both forward and backward masking trials with multiple stimulus onset asynchronies for four masking conditions at three time points (baseline, 6-month, and 18-month). Recent-onset schizophrenia patients showed stable masking performance for both forward and backward conditions over a period of 18 months. Furthermore, the stable performance was observed across all four masking conditions. The findings of this study provide further support for the view that visual masking deficits reflect a possible vulnerability marker for schizophrenia.

Original languageEnglish
Pages (from-to)266-274
Number of pages9
JournalSchizophrenia Research
Volume103
Issue number1-3
DOIs
StatePublished - Aug 2008
Externally publishedYes

Bibliographical note

Funding Information:
This work is supported by grants MH43292 to Dr. Green and MH66286 and MH37705 to Dr. Nuechterlein.

Funding

This work is supported by grants MH43292 to Dr. Green and MH66286 and MH37705 to Dr. Nuechterlein.

FundersFunder number
National Institute of Mental HealthP50MH066286

    Keywords

    • Longitudinal study
    • Recent-onset schizophrenia
    • Stability
    • Visual masking
    • Vulnerability

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