Speed and load characterization of actin-myosin nanomotor

Rajesh Kumar, Lalit M. Bharadwaj, Arun K. Lall

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations

Abstract

The functioning of any device or system essentially depends on the behaviour of the constituent materials. Nanomaterials due to their excellent mechanical properties are being used presently in almost every field. There exist nature designed nanomaterials functioning in the living systems right from the beginning of life. So, there is a need to study the specific functions being performed by these nanomaterials or nanosystems to understand their behaviour. The Actin-Myosin nanomotors which are responsible for muscle contraction phenomenon in living system have been explored in this research work. The biomechanics of the Actin and Myosin nano-motors have been studied using customized developed Matlab programs. It was observed that steps produced by the nanomotors results in relative speed up to around 5 microns/seconds during invitro motility experiments. It was found that variation in the length of the actin filament does not affect any marginal change on speed. The variation of relative speed with different loads has also been determined and it has been observed that increasing the load from 0.0054 pN to 0.145 pN results in speed reduction from 3.32 μm/s to 1.12 μm/s. The findings can be very useful in drug delivery and nanorobotic applications.

Original languageEnglish
Pages (from-to)5488-5493
Number of pages6
JournalMaterials Today: Proceedings
Volume18
DOIs
StatePublished - 2019
Externally publishedYes
Event9th International Conference of Materials Processing and Characterization, ICMPC 2019 - Hyderabad, Andhra Pradesh, India
Duration: 8 Mar 201910 Mar 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd. All rights reserved.

Keywords

  • Load
  • Matlab
  • Nanomotors
  • Speed

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