Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers

Benjamin Ehrenberg; Adina Lavi; Yeshayahu Nitzan; Zvi Malik; H. Ladan; Fred M. Johnson; Jonathan L. Sessler

Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers

Benjamin Ehrenberg, Adina Lavi, Yeshayahu Nitzan, Zvi Malik, H. Ladan, Fred M. Johnson, Jonathan L. Sessler

Department of Physics - at Bar-Ilan University

Bar-Ilan University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

8 Scopus citations

Abstract

Two types of photosensitizers are compared here for their singlet oxygen production and in vivo sensitizing capacity: Mg²⁺ and Zn²⁺-tetrabenzoporphyrin, which have a strong Q band at the HeNe laser line; and Cd-texaphyrin, with absorption at 770 nm. The singlet oxygen quantum yields in homogeneous solutions were determined by employing a singlet oxygen-destroyable fluorescent target. Photosensitizers of bacterial and human leukemic cells were carried out with these sensitizers, in comparison with HPD and Photofrin II. The new sensitizers were found to have high quantum yields for production of singlet oxygen in solutions. They also have comparable photosensitizing capacities of bacterial cells.

Original language	English
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Publisher	Publ by Int Soc for Optical Engineering
Pages	259-263
Number of pages	5
ISBN (Print)	0819407917
State	Published - 1992
Event	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy - Los Angeles, CA, USA Duration: 20 Jan 1992 → 21 Jan 1992

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	1645
ISSN (Print)	0277-786X

Conference

Conference	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy
City	Los Angeles, CA, USA
Period	20/01/92 → 21/01/92

Cite this

Ehrenberg, B., Lavi, A., Nitzan, Y., Malik, Z., Ladan, H., Johnson, F. M., & Sessler, J. L. (1992). Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers. In Proceedings of SPIE - The International Society for Optical Engineering (pp. 259-263). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1645). Publ by Int Soc for Optical Engineering.

Ehrenberg, Benjamin ; Lavi, Adina ; Nitzan, Yeshayahu et al. / Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers. Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering, 1992. pp. 259-263 (Proceedings of SPIE - The International Society for Optical Engineering).

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title = "Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers",

abstract = "Two types of photosensitizers are compared here for their singlet oxygen production and in vivo sensitizing capacity: Mg2+ and Zn2+-tetrabenzoporphyrin, which have a strong Q band at the HeNe laser line; and Cd-texaphyrin, with absorption at 770 nm. The singlet oxygen quantum yields in homogeneous solutions were determined by employing a singlet oxygen-destroyable fluorescent target. Photosensitizers of bacterial and human leukemic cells were carried out with these sensitizers, in comparison with HPD and Photofrin II. The new sensitizers were found to have high quantum yields for production of singlet oxygen in solutions. They also have comparable photosensitizing capacities of bacterial cells.",

author = "Benjamin Ehrenberg and Adina Lavi and Yeshayahu Nitzan and Zvi Malik and H. Ladan and Johnson, {Fred M.} and Sessler, {Jonathan L.}",

year = "1992",

language = "אנגלית",

isbn = "0819407917",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "Publ by Int Soc for Optical Engineering",

pages = "259--263",

booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

note = "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy ; Conference date: 20-01-1992 Through 21-01-1992",

}

Ehrenberg, B, Lavi, A, Nitzan, Y, Malik, Z, Ladan, H, Johnson, FM & Sessler, JL 1992, Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers. in Proceedings of SPIE - The International Society for Optical Engineering. Proceedings of SPIE - The International Society for Optical Engineering, vol. 1645, Publ by Int Soc for Optical Engineering, pp. 259-263, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, Los Angeles, CA, USA, 20/01/92.

Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers. / Ehrenberg, Benjamin; Lavi, Adina; Nitzan, Yeshayahu et al.
Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering, 1992. p. 259-263 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1645).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers

AU - Ehrenberg, Benjamin

AU - Lavi, Adina

AU - Nitzan, Yeshayahu

AU - Malik, Zvi

AU - Ladan, H.

AU - Johnson, Fred M.

AU - Sessler, Jonathan L.

PY - 1992

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N2 - Two types of photosensitizers are compared here for their singlet oxygen production and in vivo sensitizing capacity: Mg2+ and Zn2+-tetrabenzoporphyrin, which have a strong Q band at the HeNe laser line; and Cd-texaphyrin, with absorption at 770 nm. The singlet oxygen quantum yields in homogeneous solutions were determined by employing a singlet oxygen-destroyable fluorescent target. Photosensitizers of bacterial and human leukemic cells were carried out with these sensitizers, in comparison with HPD and Photofrin II. The new sensitizers were found to have high quantum yields for production of singlet oxygen in solutions. They also have comparable photosensitizing capacities of bacterial cells.

AB - Two types of photosensitizers are compared here for their singlet oxygen production and in vivo sensitizing capacity: Mg2+ and Zn2+-tetrabenzoporphyrin, which have a strong Q band at the HeNe laser line; and Cd-texaphyrin, with absorption at 770 nm. The singlet oxygen quantum yields in homogeneous solutions were determined by employing a singlet oxygen-destroyable fluorescent target. Photosensitizers of bacterial and human leukemic cells were carried out with these sensitizers, in comparison with HPD and Photofrin II. The new sensitizers were found to have high quantum yields for production of singlet oxygen in solutions. They also have comparable photosensitizing capacities of bacterial cells.

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BT - Proceedings of SPIE - The International Society for Optical Engineering

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Ehrenberg B, Lavi A, Nitzan Y, Malik Z, Ladan H, Johnson FM et al. Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers. In Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering. 1992. p. 259-263. (Proceedings of SPIE - The International Society for Optical Engineering).

Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers

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