Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells

Benjamin Ehrenberg; Eitan Gross; Adina Lavi; Fred M. Johnson; Zvi Malik

Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells

Benjamin Ehrenberg, Eitan Gross, Adina Lavi, Fred M. Johnson, Zvi Malik

Department of Physics

Bar-Ilan University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

The photosensitization mechanism and kinetics of hematoporphyrin derivative (HPD), photofrin II (PF-II) and Zn²⁺-phthalocyanine tetrahydroxyl (ZnPC) are compared with the newly introduced sensitizers Zn²⁺ and Mg²⁺-tetrabenzoporphyrin (ZnTBP and MgTBP), in lipid vesicles. 9,10-dimethyl anthracene was used as a fluorescent target for singlet oxygen-mediated photosensitization. From the kinetics the quantum yield of singlet oxygen generation was calculated. MgTBP is compared with hematoporphyrin for the ability to photodamage bacterial cells and human cancer cells. MgTBP was found to have a comparable capacity for such a biological effect.

Original language	English
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Publisher	Publ by Int Soc for Optical Engineering
Pages	244-251
Number of pages	8
ISBN (Print)	0819405167
State	Published - 1991
Event	Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques - Los Angeles, CA, USA Duration: 23 Jan 1991 → 25 Jan 1991

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	1426
ISSN (Print)	0277-786X

Conference

Conference	Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques
City	Los Angeles, CA, USA
Period	23/01/91 → 25/01/91

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Ehrenberg, B., Gross, E., Lavi, A., Johnson, F. M., & Malik, Z. (1991). Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells. In Proceedings of SPIE - The International Society for Optical Engineering (pp. 244-251). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1426). Publ by Int Soc for Optical Engineering.

Ehrenberg, Benjamin ; Gross, Eitan ; Lavi, Adina et al. / Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells. Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering, 1991. pp. 244-251 (Proceedings of SPIE - The International Society for Optical Engineering).

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title = "Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells",

abstract = "The photosensitization mechanism and kinetics of hematoporphyrin derivative (HPD), photofrin II (PF-II) and Zn2+-phthalocyanine tetrahydroxyl (ZnPC) are compared with the newly introduced sensitizers Zn2+ and Mg2+-tetrabenzoporphyrin (ZnTBP and MgTBP), in lipid vesicles. 9,10-dimethyl anthracene was used as a fluorescent target for singlet oxygen-mediated photosensitization. From the kinetics the quantum yield of singlet oxygen generation was calculated. MgTBP is compared with hematoporphyrin for the ability to photodamage bacterial cells and human cancer cells. MgTBP was found to have a comparable capacity for such a biological effect.",

author = "Benjamin Ehrenberg and Eitan Gross and Adina Lavi and Johnson, {Fred M.} and Zvi Malik",

year = "1991",

language = "אנגלית",

isbn = "0819405167",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "Publ by Int Soc for Optical Engineering",

pages = "244--251",

booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

note = "Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques ; Conference date: 23-01-1991 Through 25-01-1991",

}

Ehrenberg, B, Gross, E, Lavi, A, Johnson, FM & Malik, Z 1991, Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells. in Proceedings of SPIE - The International Society for Optical Engineering. Proceedings of SPIE - The International Society for Optical Engineering, vol. 1426, Publ by Int Soc for Optical Engineering, pp. 244-251, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, Los Angeles, CA, USA, 23/01/91.

Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells. / Ehrenberg, Benjamin; Gross, Eitan; Lavi, Adina et al.
Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering, 1991. p. 244-251 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1426).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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N2 - The photosensitization mechanism and kinetics of hematoporphyrin derivative (HPD), photofrin II (PF-II) and Zn2+-phthalocyanine tetrahydroxyl (ZnPC) are compared with the newly introduced sensitizers Zn2+ and Mg2+-tetrabenzoporphyrin (ZnTBP and MgTBP), in lipid vesicles. 9,10-dimethyl anthracene was used as a fluorescent target for singlet oxygen-mediated photosensitization. From the kinetics the quantum yield of singlet oxygen generation was calculated. MgTBP is compared with hematoporphyrin for the ability to photodamage bacterial cells and human cancer cells. MgTBP was found to have a comparable capacity for such a biological effect.

AB - The photosensitization mechanism and kinetics of hematoporphyrin derivative (HPD), photofrin II (PF-II) and Zn2+-phthalocyanine tetrahydroxyl (ZnPC) are compared with the newly introduced sensitizers Zn2+ and Mg2+-tetrabenzoporphyrin (ZnTBP and MgTBP), in lipid vesicles. 9,10-dimethyl anthracene was used as a fluorescent target for singlet oxygen-mediated photosensitization. From the kinetics the quantum yield of singlet oxygen generation was calculated. MgTBP is compared with hematoporphyrin for the ability to photodamage bacterial cells and human cancer cells. MgTBP was found to have a comparable capacity for such a biological effect.

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BT - Proceedings of SPIE - The International Society for Optical Engineering

PB - Publ by Int Soc for Optical Engineering

T2 - Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques

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Ehrenberg B, Gross E, Lavi A, Johnson FM, Malik Z. Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells. In Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering. 1991. p. 244-251. (Proceedings of SPIE - The International Society for Optical Engineering).

Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells

Abstract

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UN SDGs

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