Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Tomer Illouz, Arya Biragyn, Milana Frenkel-Morgenstern, Orly Weissberg, Alessandro Gorohovski, Eugene Merzon, Ilan Green, Florencia Iulita, Lisi Flores-Aguilar, Mara Dierssen, Ilario De Toma, Hefziba Lifshitz, Stylianos E. Antonarakis, Eugene Yu, Yann Herault, Marie Claude Potier, Alexandra Botté, Randall Roper, Benjamin Sredni, Ronit SaridJacqueline London, William Mobley, Andre Strydom, Eitan Okun

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer’s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.

Original languageEnglish
Pages (from-to)561-571
Number of pages11
JournalNeuroMolecular Medicine
Volume23
Issue number4
DOIs
StatePublished - Dec 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).

Funding

This research was supported in part by the Intramural Research Program of the National Institute on Aging. We thank Yael Laure for thorough editing of the manuscript. This research was supported by the Trisomy-21 Research Society (T21RS). This research was supported in part by the Intramural Research Program of the National Institute on Aging. We thank Yael Laure for thorough editing of the manuscript.

FundersFunder number
Trisomy-21 Research SocietyT21RS
National Institute on AgingZIAAG000444

    Keywords

    • COVID-19
    • Down syndrome
    • Immune dysregulation
    • SARS-CoV-2
    • Vaccine

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