TY - JOUR
T1 - Specific measures of executive function predict cognitive decline in older adults
AU - Clark, Lindsay R.
AU - Schiehser, Dawn M.
AU - Weissberger, Gali H.
AU - Salmon, David P.
AU - Delis, Dean C.
AU - Bondi, Mark W.
PY - 2012/1
Y1 - 2012/1
N2 - Decline in executive function has been noted in the prodromal stage of Alzheimer's disease (AD) and may presage more global cognitive declines. In this prospective longitudinal study, five measures of executive function were used to predict subsequent global cognitive decline in initially nondemented older adults. Of 71 participants, 15 demonstrated significant decline over a 1-year period on the Dementia Rating Scale (Mattis, 1988) and the remaining participants remained stable. In the year before decline, the decline group performed significantly worse than the no-decline group on two measures of executive function: the Color-Word Interference Test (CWIT; inhibition/switching condition) and Verbal Fluency (VF; switching condition). In contrast, decliners and non-decliners performed similarly on measures of spatial fluency (Design Fluency switching condition), spatial planning (Tower Test), and number-letter switching (Trail Making Test switching condition). Furthermore, the CWIT inhibition-switching measure significantly improved the prediction of decline and no-decline group classification beyond that of learning and memory measures. These findings suggest that some executive function measures requiring inhibition and switching provide predictive utility of subsequent global cognitive decline independent of episodic memory and may further facilitate early detection of dementia.
AB - Decline in executive function has been noted in the prodromal stage of Alzheimer's disease (AD) and may presage more global cognitive declines. In this prospective longitudinal study, five measures of executive function were used to predict subsequent global cognitive decline in initially nondemented older adults. Of 71 participants, 15 demonstrated significant decline over a 1-year period on the Dementia Rating Scale (Mattis, 1988) and the remaining participants remained stable. In the year before decline, the decline group performed significantly worse than the no-decline group on two measures of executive function: the Color-Word Interference Test (CWIT; inhibition/switching condition) and Verbal Fluency (VF; switching condition). In contrast, decliners and non-decliners performed similarly on measures of spatial fluency (Design Fluency switching condition), spatial planning (Tower Test), and number-letter switching (Trail Making Test switching condition). Furthermore, the CWIT inhibition-switching measure significantly improved the prediction of decline and no-decline group classification beyond that of learning and memory measures. These findings suggest that some executive function measures requiring inhibition and switching provide predictive utility of subsequent global cognitive decline independent of episodic memory and may further facilitate early detection of dementia.
KW - Executive functions
KW - Global cognition
KW - Mild cognitive impairment
KW - Prediction
KW - Prodromal Alzheimer's disease
KW - Switching
UR - http://www.scopus.com/inward/record.url?scp=84855163601&partnerID=8YFLogxK
U2 - 10.1017/S1355617711001524
DO - 10.1017/S1355617711001524
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C2 - 22115028
AN - SCOPUS:84855163601
SN - 1355-6177
VL - 18
SP - 118
EP - 127
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 1
ER -