TY - JOUR
T1 - Spatial-temporal correlations in the speckle pattern for the characterization of cellular motion within a 3D object
AU - Weil, Y
AU - Shafran, Y
AU - Sobolev, M
AU - Afrimzon, L
AU - Zurgil, N
AU - Deutsch, M
AU - Schiffer, Z
N1 - Publisher Copyright:
© 2023 Optica Publishing Group.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Dynamic light scattering analysis has been demonstrated recently to be a promising tool for the assessment of structural changes taking place inside opaque tissue samples. Specifically, quantification of velocity and direction of cellular motion inside spheroids and organoids has attracted much attention as a potent indicator in personalized therapy research. Here, we propose a method for the quantitative extraction of cellular motion, velocity, and direction, by applying a concept of speckle spatial-temporal correlation dynamics. Numerical simulations and experimental results obtained on phantom and biological spheroids are presented. (c) 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
AB - Dynamic light scattering analysis has been demonstrated recently to be a promising tool for the assessment of structural changes taking place inside opaque tissue samples. Specifically, quantification of velocity and direction of cellular motion inside spheroids and organoids has attracted much attention as a potent indicator in personalized therapy research. Here, we propose a method for the quantitative extraction of cellular motion, velocity, and direction, by applying a concept of speckle spatial-temporal correlation dynamics. Numerical simulations and experimental results obtained on phantom and biological spheroids are presented. (c) 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=barilanwos&SrcAuth=WosAPI&KeyUT=WOS:000993277900002&DestLinkType=FullRecord&DestApp=WOS
UR - http://www.scopus.com/inward/record.url?scp=85201589967&partnerID=8YFLogxK
U2 - 10.1364/boe.476526
DO - 10.1364/boe.476526
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C2 - 37206140
SN - 2156-7085
VL - 14
SP - 1974
EP - 1991
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 5
ER -