Spared perception of object geometry and object components after hippocampal damage

Zhisen J. Urgolites; Daniel A. Levy; Ramona O. Hopkins; Larry R. Squire

doi:10.1101/lm.047464.118

Spared perception of object geometry and object components after hippocampal damage

Zhisen J. Urgolites
, Daniel A. Levy
, Ramona O. Hopkins
, Larry R. Squire

Department of Veterans Affairs
Reichman University
Brigham Young University
Primary Children's Medical Center
University of California at San Diego

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We tested the proposal that medial temporal lobe (MTL) structures support not just memory but also high-level object perception. In one task, participants decided whether a line drawing could represent an object in three-dimensional space and, in another task, they saw the components of an object and decided what object could be formed if the components were assembled. Patients with hippocampal lesions were intact, indicating that the hippocampus is not needed for perceiving the structural coherence of objects or appreciating the relations among object parts. Patients with large MTL lesions were moderately impaired, likely due to damage outside the MTL.

Original language	English
Pages (from-to)	330-334
Number of pages	5
Journal	Learning and Memory
Volume	25
Issue number	7
DOIs	https://doi.org/10.1101/lm.047464.118
State	Published - Jul 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Urgolites et al.

Funding

This work was supported by the Medical Research Service of the Department of Veterans Affairs (I01CS000359) and NIMH (Grant 24600). We thank the UCSD Shiley-Marcos Alzheimer’s Disease Research Center (Grant P50AG005131) for providing structural magnetic resonance imaging (MRI) scans for healthy older males. We also thank Nancy Kanwisher, Russel Epstein, and Christine Smith for helpful discussions, and Jennifer Frascino, Nadine Heyworth, Soyun Kim, and Ashley Knutson for assistance.

Funders	Funder number
National Institute of Mental Health	24600
National Institute on Aging	P50AG005131
U.S. Department of Veterans Affairs	I01CS000359

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Spared perception of object geometry and object components after hippocampal damage

Abstract

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