Sonochemically-fabricated Ga@C-dots@Ga nanoparticle-aided neural growth

Ifat Nissan, Vijay Bhooshan Kumar, Ze'ev Porat, Darko Makovec, Orit Shefi, Aharon Gedanken

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

In this paper, we report the fabrication of an antibacterial material, Ga-doped C-dots on Ga nanoparticles (Ga@C-dots@Ga NPs), which is deposited on a glass substrate for neural growth. A one-step sonochemical process is applied for the simultaneous fabrication and coating of Ga@C-dots@Ga NPs using PEG 400 and molten gallium. The physical and chemical characteristics of the synthesized materials were studied using scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), fluorescence analysis, dynamic light scattering (DLS) and other techniques. SH-SY5Y cells were plated on the substrates. The effect of the Ga@C-dots@Ga NPs on the development of neurites during the initiation and elongation growth phases was studied and compared with C-dots, Ga@C-dots and Ga NPs. Our research focuses on the influence of the physical and chemical properties of composites on neurite growth. We observed that cells grown on a Ga@C-dots@Ga-coated substrate exhibit a 97% increase in the number of branches originating from the soma. We found that surface modification and particle morphology play a significant role in the neural growth.

Original languageEnglish
Pages (from-to)1371-1379
Number of pages9
JournalJournal of Materials Chemistry B
Volume5
Issue number7
DOIs
StatePublished - 21 Feb 2017

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

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