TY - JOUR
T1 - Sonochemical stabilization of ultrafine colloidal biocompatible magnetite nanoparticles using amino acid, l-arginine, for possible bio applications
AU - Theerdhala, Sriharsha
AU - Bahadur, Dhirendra
AU - Vitta, Satish
AU - Perkas, Nina
AU - Zhong, Ziyi
AU - Gedanken, Aharon
PY - 2010/4
Y1 - 2010/4
N2 - Materials obtained by the synergistic combination of nanotechnology and biomedicine are an important source of drug delivery and other health care related applications. The anchoring of amino acids onto the surface of nano-sized magnetite is one such example. Herein, we report on the binding of a semi-essential amino acid, l-arginine, onto the surface of nano magnetite, creating a stable aqueous suspension by an in situ one-step method using sonochemical synthesis. An ex situ two-step process was also attempted, but was soon discarded owing to the relative short duration of the suspension attributed to increase in particle size and lower extent of binding. The initial concentration of the amino acid was found to play an important role in controlling the particle size and also the binding motif. Lower concentrations of arginine were found to favor the formation of elongated tubular structures, while at higher concentrations, the elongated structures were less prominent and arginine was found to be adsorbed onto the surface of the magnetite. This surface-functionalized nanomagnetite with amino acids could become a promising vehicle for drug delivery.
AB - Materials obtained by the synergistic combination of nanotechnology and biomedicine are an important source of drug delivery and other health care related applications. The anchoring of amino acids onto the surface of nano-sized magnetite is one such example. Herein, we report on the binding of a semi-essential amino acid, l-arginine, onto the surface of nano magnetite, creating a stable aqueous suspension by an in situ one-step method using sonochemical synthesis. An ex situ two-step process was also attempted, but was soon discarded owing to the relative short duration of the suspension attributed to increase in particle size and lower extent of binding. The initial concentration of the amino acid was found to play an important role in controlling the particle size and also the binding motif. Lower concentrations of arginine were found to favor the formation of elongated tubular structures, while at higher concentrations, the elongated structures were less prominent and arginine was found to be adsorbed onto the surface of the magnetite. This surface-functionalized nanomagnetite with amino acids could become a promising vehicle for drug delivery.
KW - Amino acid
KW - Drug delivery
KW - Magnetite
KW - Sonochemistry
KW - Stable colloidal solution
UR - http://www.scopus.com/inward/record.url?scp=77649273917&partnerID=8YFLogxK
U2 - 10.1016/j.ultsonch.2009.12.007
DO - 10.1016/j.ultsonch.2009.12.007
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C2 - 20042358
AN - SCOPUS:77649273917
SN - 1350-4177
VL - 17
SP - 730
EP - 737
JO - Ultrasonics Sonochemistry
JF - Ultrasonics Sonochemistry
IS - 4
ER -