Some Epinephrine Analogs

Ernst D. Bergmann; Zeev Goldschmidt

doi:10.1021/jm00312a004

Some Epinephrine Analogs

Ernst D. Bergmann, Zeev Goldschmidt

Hebrew University of Jerusalem

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17 Scopus citations

Abstract

A number of epinephrine analogs and corresponding 1-aryl-2-alkylaminoethyl chloride hydrochlorides and bromide hydrobromides have been prepared. The central intermediates of the syntheses were the 5-aryl-3-alkyl-2-oxazolidones (IV), accessible by alkylation of the product obtained using the Reformatzky reaction of an aromatic aldehyde with ethyl bromoacetate. The results of a pharmacological study of the products obtained are summarized.

Original language	English
Pages (from-to)	1121-1125
Number of pages	5
Journal	Journal of Medicinal Chemistry
Volume	11
Issue number	6
DOIs	https://doi.org/10.1021/jm00312a004
State	Published - 1 Sep 1968
Externally published	Yes

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abstract = "A number of epinephrine analogs and corresponding 1-aryl-2-alkylaminoethyl chloride hydrochlorides and bromide hydrobromides have been prepared. The central intermediates of the syntheses were the 5-aryl-3-alkyl-2-oxazolidones (IV), accessible by alkylation of the product obtained using the Reformatzky reaction of an aromatic aldehyde with ethyl bromoacetate. The results of a pharmacological study of the products obtained are summarized.",

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AB - A number of epinephrine analogs and corresponding 1-aryl-2-alkylaminoethyl chloride hydrochlorides and bromide hydrobromides have been prepared. The central intermediates of the syntheses were the 5-aryl-3-alkyl-2-oxazolidones (IV), accessible by alkylation of the product obtained using the Reformatzky reaction of an aromatic aldehyde with ethyl bromoacetate. The results of a pharmacological study of the products obtained are summarized.

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Some Epinephrine Analogs

Abstract

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