Solid support based synthesis of 1,5-benzodiazepines: A mini review

Ruby Mishra, Atul Kumar Sharma, Rajesh Kumar, Varsha Baweja, Poonam Mothsra, Manoj K. Singh, Shyam Bharat Yadav

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


1,5-Benzodiazepines are one of the most important class of N-containing bicyclic heterocyclic compounds due to their extraordinary biological and pharmacological properties. The biological properties shown by bicyclic benzodiazepines in many fields has prompted the organic chemist to design and preparation of new benzodiazepines and their derivatives as potential therapeutic agents with improved biological properties. This review is primarily focused on different solid supported catalysts, such as graphene oxide, silica, clay, magnesium oxide, iron oxide, zeolite, and other miscellaneous catalysts for the one-pot, economical, greener and environmentally benign synthesis of 1,5-benzodiazepines and its derivatives.

Original languageEnglish
Pages (from-to)481-503
Number of pages23
JournalSynthetic Communications
Issue number4
StatePublished - 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.


  • 1,5-benzodiapenes
  • Antidepressants
  • heterogeneous catalyst
  • neurotransmitters
  • solid support


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