Sodium glucose cotransporter 2 inhibitors treatment in acromegalic patients with diabetes—a case series and literature review

Adnan Zaina, Yuval Grober, Ali Abid, Eldad Arad, Elena Golden, Samih Badarny

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Purpose: Diabetes mellitus (DM) represents one of the most frequent comorbidities in patients with acromegaly. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) represent an important class for diabetes management. However, limited data is reported regarding the use of this class in patients with acromegaly and diabetes. Methods: Reporting data regarding patients with acromegaly and diabetes under treatment with SGLT2i. Results: 29 acromegalic patients with diabetes were identified. Treatment with SGLT-2i was documented in nine patients, out of them 5 females and 4 males with a mean age (SD) of 61 ± 12 yr. The mean (SD) duration of treatment with SGLT2i was 27.5 ± 7.3 months. Mean HbA1c before and after SGLT-2i initiation was 8.1 ± 1.1 and 7.0 ± 0.9% respectively. Mean IGF-1 level (SD) before SGLT-2i initiation was 177 ± 68 ng/mL and the mean GH level (SD) was 0.7 ± 0.5 µg/L. All nine patients are still under treatment with SGLT2i and none of them had reported any adverse reaction related to SGLT2i. Conclusions: The present article provides us for the first time with new data regarding the use of SGLT2i among acromegalic patients with diabetes.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalEndocrine
Volume73
Issue number1
DOIs
StatePublished - Jul 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Acromegaly
  • Diabetes
  • Diabetic ketoacidosis
  • SGLT2i

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