TY - JOUR
T1 - Sodium aurothiomalate does not block interleukin 1 production in rabbits
AU - Zurovsky, Y.
AU - Laburn, H. P.
AU - Mitchell, D.
AU - Ruck, A.
PY - 1988/6
Y1 - 1988/6
N2 - Gold salts may attenuate inflammatory processes by inhibiting interleukin 1 production. It is shown that sodium aurothiomalate does not act as an antipyretic after intravenous injection of two pyrogens into rabbits. Consequently, it cannot suppress interleukin 1 production, a conclusion confirmed by an in vitro lymphocyte activating factor assay. Chronic sodium aurothiomalate treatment, however, did depress the blood leucocyte count significantly.
AB - Gold salts may attenuate inflammatory processes by inhibiting interleukin 1 production. It is shown that sodium aurothiomalate does not act as an antipyretic after intravenous injection of two pyrogens into rabbits. Consequently, it cannot suppress interleukin 1 production, a conclusion confirmed by an in vitro lymphocyte activating factor assay. Chronic sodium aurothiomalate treatment, however, did depress the blood leucocyte count significantly.
UR - http://www.scopus.com/inward/record.url?scp=0023920505&partnerID=8YFLogxK
U2 - 10.1136/ard.47.6.506
DO - 10.1136/ard.47.6.506
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C2 - 3132899
AN - SCOPUS:0023920505
SN - 0003-4967
VL - 47
SP - 506
EP - 508
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 6
ER -