Sodium aurothiomalate does not block interleukin 1 production in rabbits

Y. Zurovsky, H. P. Laburn, D. Mitchell, A. Ruck

Research output: Contribution to journalArticlepeer-review


Gold salts may attenuate inflammatory processes by inhibiting interleukin 1 production. It is shown that sodium aurothiomalate does not act as an antipyretic after intravenous injection of two pyrogens into rabbits. Consequently, it cannot suppress interleukin 1 production, a conclusion confirmed by an in vitro lymphocyte activating factor assay. Chronic sodium aurothiomalate treatment, however, did depress the blood leucocyte count significantly.

Original languageEnglish
Pages (from-to)506-508
Number of pages3
JournalAnnals of the Rheumatic Diseases
Issue number6
StatePublished - 1988
Externally publishedYes


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