Sleep in Fish Models

A. C. Keene; L. Appelbaum

doi:10.1016/b978-0-12-813743-7.00024-4

Sleep in Fish Models

A. C. Keene, L. Appelbaum

The Mina and Everard Goodman Faculty of Life Sciences

Florida Atlantic University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

12 Scopus citations

Abstract

Sleep is a near-universal behavior that is essential for diverse biological processes. Although the duration and timing of sleep vary throughout the animal kingdom, the function of sleep and the evolutionary basis for this conserved behavior remain poorly understood. In recent years, characterization of sleep in fish models has provided fundamental insights into the molecular, cellular, and evolutionary principles of sleep regulation. Here, we outline the breakthroughs in fish for sleep research and the strengths of fish models for sleep investigation. We focus this review on research in zebrafish (Danio rerio) and the Mexican cavefish (Astyanax mexicanus) that investigates the mechanisms of sleep regulation and the evolution of sleep in response to environmental perturbation. We propose that developing new genetic tools and applying the current available toolkit to additional fish models of evolution, behavior, aging, and neurological disorders will augment our understanding of the mechanisms and function of sleep.

Original language	English
Title of host publication	Handbook of Behavioral Neuroscience
Publisher	Elsevier B.V.
Pages	363-374
Number of pages	12
DOIs	https://doi.org/10.1016/b978-0-12-813743-7.00024-4
State	Published - 2019

Publication series

Name	Handbook of Behavioral Neuroscience
Volume	30
ISSN (Print)	1569-7339

Bibliographical note

Publisher Copyright:
© 2019 Elsevier B.V.

Funding

This work was supported by the Israel Science Foundation (grant no. 690/15 to LA), the United States—Israel Binational Science Foundation (BSF, grant no. 2017105 to LA and AK)—and a US National Science Foundation Award (NSF, grant no. 165674 to AK). David Zada, Talia Levitas-Djerbi, and Idan Elbaz generated the pictures presented in Fig. 24.1 .

Funders	Funder number
National Science Foundation	165674
Bloom's Syndrome Foundation	2017105
United States-Israel Binational Science Foundation
Israel Science Foundation	690/15

Keywords

Circadian
Evolution
Genomics
Hypocretin/orexin
Lateral line
Live imaging
Mexican cavefish
Neuronal-circuits
Sleep
Zebrafish

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10.1016/b978-0-12-813743-7.00024-4

Cite this

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Sleep in Fish Models

Abstract

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Bibliographical note

Funding

Keywords

Access to Document

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