Sleep apnea awakens cancer: A unifying immunological hypothesis

David Gozal; Isaac Almendros; Fahed Hakim

doi:10.4161/onci.28326

Sleep apnea awakens cancer: A unifying immunological hypothesis

David Gozal
, Isaac Almendros
, Fahed Hakim

The University of Chicago

Research output: Contribution to journal › Comment/debate

27 Scopus citations

Abstract

The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OS A, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness.

Original language	English
Article number	e28326
Journal	OncoImmunology
Volume	3
Issue number	3
DOIs	https://doi.org/10.4161/onci.28326
State	Published - 2014
Externally published	Yes

Bibliographical note

Funding Information:
D.G. is supported by National Institutes of Health grants HL-65270, HL-086662, and HL-107160. I.A. is supported by Beatriu de Pinós fellow ship from Generalitat de Catalunya (2010 BP_A 00238).

Funding

D.G. is supported by National Institutes of Health grants HL-65270, HL-086662, and HL-107160. I.A. is supported by Beatriu de Pinós fellow ship from Generalitat de Catalunya (2010 BP_A 00238).

Funders	Funder number
National Institutes of Health	HL-107160, HL-086662, HL-65270
Generalitat de Catalunya	2010 BP_A 00238

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angiogenesis
Intermittent hypoxia
Invasion
Macrophage polarity
Sleep apnea
Sleep fragmentation

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10.4161/onci.28326

Cite this

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abstract = "The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OS A, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness.",

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AU - Almendros, Isaac

AU - Hakim, Fahed

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N2 - The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OS A, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness.

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KW - Intermittent hypoxia

KW - Invasion

KW - Macrophage polarity

KW - Sleep apnea

KW - Sleep fragmentation

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Sleep apnea awakens cancer: A unifying immunological hypothesis

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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