Sleep apnea awakens cancer: A unifying immunological hypothesis

David Gozal; Isaac Almendros; Fahed Hakim

doi:10.4161/onci.28326

Sleep apnea awakens cancer: A unifying immunological hypothesis

David Gozal, Isaac Almendros, Fahed Hakim

The University of Chicago

Research output: Contribution to journal › Comment/debate

25 Scopus citations

Abstract

The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OS A, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness.

Original language	English
Article number	e28326
Journal	OncoImmunology
Volume	3
Issue number	3
DOIs	https://doi.org/10.4161/onci.28326
State	Published - 2014
Externally published	Yes

Bibliographical note

Funding Information:
D.G. is supported by National Institutes of Health grants HL-65270, HL-086662, and HL-107160. I.A. is supported by Beatriu de Pinós fellow ship from Generalitat de Catalunya (2010 BP_A 00238).

Keywords

Angiogenesis
Intermittent hypoxia
Invasion
Macrophage polarity
Sleep apnea
Sleep fragmentation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4161/onci.28326

Cite this

@article{333bdfbd3ed44e59b2fac5d21a688031,

title = "Sleep apnea awakens cancer: A unifying immunological hypothesis",

abstract = "The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OS A, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness.",

keywords = "Angiogenesis, Intermittent hypoxia, Invasion, Macrophage polarity, Sleep apnea, Sleep fragmentation",

author = "David Gozal and Isaac Almendros and Fahed Hakim",

note = "Funding Information: D.G. is supported by National Institutes of Health grants HL-65270, HL-086662, and HL-107160. I.A. is supported by Beatriu de Pin{\'o}s fellow ship from Generalitat de Catalunya (2010 BP_A 00238).",

year = "2014",

doi = "10.4161/onci.28326",

language = "אנגלית",

volume = "3",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Landes Bioscience",

number = "3",

}

TY - JOUR

T1 - Sleep apnea awakens cancer

T2 - A unifying immunological hypothesis

AU - Gozal, David

AU - Almendros, Isaac

AU - Hakim, Fahed

N1 - Funding Information: D.G. is supported by National Institutes of Health grants HL-65270, HL-086662, and HL-107160. I.A. is supported by Beatriu de Pinós fellow ship from Generalitat de Catalunya (2010 BP_A 00238).

PY - 2014

Y1 - 2014

N2 - The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OS A, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness.

AB - The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OS A, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness.

KW - Angiogenesis

KW - Intermittent hypoxia

KW - Invasion

KW - Macrophage polarity

KW - Sleep apnea

KW - Sleep fragmentation

UR - http://www.scopus.com/inward/record.url?scp=84902439150&partnerID=8YFLogxK

U2 - 10.4161/onci.28326

DO - 10.4161/onci.28326

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.comment???

AN - SCOPUS:84902439150

SN - 2162-4011

VL - 3

JO - OncoImmunology

JF - OncoImmunology

IS - 3

M1 - e28326

ER -

Sleep apnea awakens cancer: A unifying immunological hypothesis

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this