SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia

David R. Betts; Racheli Stanchescu; Felix K. Niggli; Ninette Cohen; Gideon Rechavi; Ninette Amariglio; Luba Trakhtenbrot

doi:10.1016/j.leukres.2007.03.010

SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia

David R. Betts, Racheli Stanchescu, Felix K. Niggli, Ninette Cohen, Gideon Rechavi, Ninette Amariglio, Luba Trakhtenbrot

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The G-band cryptic t(12;21)(p13;q22) is the most common chromosomal rearrangement in childhood acute lymphoblastic leukemia (ALL). To investigate the nature of additional chromosomal events in this group of patients spectral karyotyping (SKY) following G-banding analysis was performed in 14 cases. From these cases six showed structural aberrations of chromosome 6, including both simple deletions and unbalanced translocations, and involved both q (n = 4) and p (n = 3) arms. The results show that rearrangements of 6p are also non-random events t(12;21)-positive ALL. This study illustrates the value of a combined SKY and G-banding approach in identifying novel karyotypic events in childhood ALL.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	Leukemia Research
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2007.03.010
State	Published - Jan 2008
Externally published	Yes

Keywords

Acute lymphoblastic leukemia
Child
Karyotyping
SKY

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2007.03.010

Cite this

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title = "SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia",

abstract = "The G-band cryptic t(12;21)(p13;q22) is the most common chromosomal rearrangement in childhood acute lymphoblastic leukemia (ALL). To investigate the nature of additional chromosomal events in this group of patients spectral karyotyping (SKY) following G-banding analysis was performed in 14 cases. From these cases six showed structural aberrations of chromosome 6, including both simple deletions and unbalanced translocations, and involved both q (n = 4) and p (n = 3) arms. The results show that rearrangements of 6p are also non-random events t(12;21)-positive ALL. This study illustrates the value of a combined SKY and G-banding approach in identifying novel karyotypic events in childhood ALL.",

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year = "2008",

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doi = "10.1016/j.leukres.2007.03.010",

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AU - Betts, David R.

AU - Stanchescu, Racheli

AU - Niggli, Felix K.

AU - Cohen, Ninette

AU - Rechavi, Gideon

AU - Amariglio, Ninette

AU - Trakhtenbrot, Luba

PY - 2008/1

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AB - The G-band cryptic t(12;21)(p13;q22) is the most common chromosomal rearrangement in childhood acute lymphoblastic leukemia (ALL). To investigate the nature of additional chromosomal events in this group of patients spectral karyotyping (SKY) following G-banding analysis was performed in 14 cases. From these cases six showed structural aberrations of chromosome 6, including both simple deletions and unbalanced translocations, and involved both q (n = 4) and p (n = 3) arms. The results show that rearrangements of 6p are also non-random events t(12;21)-positive ALL. This study illustrates the value of a combined SKY and G-banding approach in identifying novel karyotypic events in childhood ALL.

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KW - Karyotyping

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SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia

Abstract

Keywords

UN SDGs

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