Skoura - A genetic island for congenital insensitivity to pain and anhidrosis among Moroccan Jews, as determined by a novel mutation in the NTRK1 gene

C. Suriu, M. Khayat, M. Weiler, N. Kfir, C. Cohen, A. Zinger, C. Aslanidis, G. Schmitz, Tzipora C. Falik-Zaccai

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV is a rare, autosomal recessive neurologic disorder, characterized by absence of reaction to painful stimuli, mental retardation, self-mutilating behavior, anhidrosis, and recurrent episodes of hyperthermia. Mutations in the neurotrophic tyrosine kinase receptor 1, a receptor phosphorylated by nerve growth factor, have been documented in diverse ethnic groups. We identified the same novel nonsense mutation in two unrelated families of Moroccan Jewish descent, each with two affected siblings. This possible founder mutation may trace to the rural Jewish village in southern Morocco from where both these families originated. Genetic screening for the causative mutation among 300 unrelated Moroccan Jews did not reveal carriers for the causative mutation, thus excluding high risk for CIPA in this ethnic subpopulation.

Original languageEnglish
Pages (from-to)230-236
Number of pages7
JournalClinical Genetics
Volume75
Issue number3
DOIs
StatePublished - Mar 2009
Externally publishedYes

Keywords

  • CIPA
  • Hereditary sensory and autonomic neuropathy type IV
  • MJ
  • NGF
  • NTRK1 mutation

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