TY - JOUR
T1 - Skoura - A genetic island for congenital insensitivity to pain and anhidrosis among Moroccan Jews, as determined by a novel mutation in the NTRK1 gene
AU - Suriu, C.
AU - Khayat, M.
AU - Weiler, M.
AU - Kfir, N.
AU - Cohen, C.
AU - Zinger, A.
AU - Aslanidis, C.
AU - Schmitz, G.
AU - Falik-Zaccai, Tzipora C.
PY - 2009/3
Y1 - 2009/3
N2 - Congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV is a rare, autosomal recessive neurologic disorder, characterized by absence of reaction to painful stimuli, mental retardation, self-mutilating behavior, anhidrosis, and recurrent episodes of hyperthermia. Mutations in the neurotrophic tyrosine kinase receptor 1, a receptor phosphorylated by nerve growth factor, have been documented in diverse ethnic groups. We identified the same novel nonsense mutation in two unrelated families of Moroccan Jewish descent, each with two affected siblings. This possible founder mutation may trace to the rural Jewish village in southern Morocco from where both these families originated. Genetic screening for the causative mutation among 300 unrelated Moroccan Jews did not reveal carriers for the causative mutation, thus excluding high risk for CIPA in this ethnic subpopulation.
AB - Congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV is a rare, autosomal recessive neurologic disorder, characterized by absence of reaction to painful stimuli, mental retardation, self-mutilating behavior, anhidrosis, and recurrent episodes of hyperthermia. Mutations in the neurotrophic tyrosine kinase receptor 1, a receptor phosphorylated by nerve growth factor, have been documented in diverse ethnic groups. We identified the same novel nonsense mutation in two unrelated families of Moroccan Jewish descent, each with two affected siblings. This possible founder mutation may trace to the rural Jewish village in southern Morocco from where both these families originated. Genetic screening for the causative mutation among 300 unrelated Moroccan Jews did not reveal carriers for the causative mutation, thus excluding high risk for CIPA in this ethnic subpopulation.
KW - CIPA
KW - Hereditary sensory and autonomic neuropathy type IV
KW - MJ
KW - NGF
KW - NTRK1 mutation
UR - http://www.scopus.com/inward/record.url?scp=60549097721&partnerID=8YFLogxK
U2 - 10.1111/j.1399-0004.2008.01143.x
DO - 10.1111/j.1399-0004.2008.01143.x
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C2 - 19250380
AN - SCOPUS:60549097721
SN - 0009-9163
VL - 75
SP - 230
EP - 236
JO - Clinical Genetics
JF - Clinical Genetics
IS - 3
ER -