Skin-derived micro-organs induce angiogenesis in rabbits

Eilat Hasson, Jeniffer Gallula, Yael Shimoni, Etty Grad-Itach, Moshe Marikovsky, Eduardo Mitrani

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We have recently reported an alternative cell therapy approach to induce angiogenesis. The approach is based on small organ fragments - micro-organs (MOs) - whose geometry allows preservation of the natural epithelial/mesenchymal interactions and ensures appropriate diffusion of nutrients and gases to all cells. We have shown that lung-derived MOs, when implanted into hosts, transcribe a wide spectrum array of angiogenic factors and can induce an angiogenic response that can rescue experimentally induced ischemic regions in mice. From a clinical perspective, skin-derived MOs are particularly appealing as they could readily be obtained from a skin biopsy taken from the same target patient. In the present work we have investigated the angiogenesis-inducing capacity of rabbit and human skin-derived micro-organs in vitro and in vivo. Rabbit skin MOs were implanted into homologous adult rabbits and human skin MOs were encapsulated and implanted into xenogenic mice. Skin-derived MOs, as lung-derived MOs, were found to secrete a whole array of angiogenic factors and to induce a powerful angiogenic response when implanted back into animals. We believe the approach presented suggests a novel, efficacious and simple approach for therapeutic angiogenesis.

Original languageEnglish
Pages (from-to)139-148
Number of pages10
JournalJournal of Vascular Research
Issue number2
StatePublished - Feb 2006
Externally publishedYes


  • Angiogenesis
  • Cell therapy
  • Encapsulation
  • Multifactorial approach
  • Vessel formation


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