Skin-depigmenting prodrugs of hydroquinone

A. Nudelman, Z. Ben-Ishai, M. Ruse, J. Schamroth

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Novel mono-1 and bis-carbonates 2, and mono-3 and bis-pivaloyloxymethyl ethers 4 (bis-POM-ethers) of hydroquinone (HQ) evaluated as skin-lightening agents, showed that: 1) they cause an initial depigmentation of the skin; 2) the depigmenting effect is not maintained over prolonged periods of time; and 3) prolonged use results in a shift of the chromatic locus, suggesting the formation of a new chemical product in the skin. HQ was a more potent depigmenting agent than any of the derivatives tested.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Issue number2
StatePublished - 1993


  • hydroquinone
  • prodrugs
  • skin depigmentation


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