Abstract
Sirtuins are NAD+ dependent deacylases enzymes. There are seven mammalian sirtuins, SIRT1-SIRT7, which are localized to different cellular compartments and are capable of diverse catalytic activities. SIRT6 is a key regulator of healthy ageing. In the past decade our understanding of SIRT6 significantly increased in many different aspects. We know its cellular localization, catalytic activities, substrates and the pathways it is involved in. This review discusses the recent discoveries regarding the SIRT6 enzyme.
| Original language | English |
|---|---|
| Pages (from-to) | 629-639 |
| Number of pages | 11 |
| Journal | Biogerontology |
| Volume | 14 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2013 |
Bibliographical note
Funding Information:Acknowledgments We thank the members of Cohen’s lab, in particular Shoshana Naiman, for their helpful comments on the manuscript. The research at Cohen’s lab is supported by the Israel Science Foundation, Teva Pharmaceutical Industries LTD, I-Core Foundation, Israeli Ministry of Health, and the ERC: European Research Council.
Funding
Acknowledgments We thank the members of Cohen’s lab, in particular Shoshana Naiman, for their helpful comments on the manuscript. The research at Cohen’s lab is supported by the Israel Science Foundation, Teva Pharmaceutical Industries LTD, I-Core Foundation, Israeli Ministry of Health, and the ERC: European Research Council.
| Funders | Funder number |
|---|---|
| I-Core Foundation | |
| Teva Pharmaceutical Industries | |
| Seventh Framework Programme | 242763 |
| European Commission | |
| Israel Science Foundation | |
| Ministry of Health, State of Israel |
Keywords
- Ageing
- Deacylation
- SIRT6