Abstract
Two thio-urea based bifunctional probes (H2L1-S and H2L2-S) have been designed and fabricated for the colorimetric and fluorometric detection of mercury(II) and acetate ions respectively in DMSO media. Both the H2L1-S and H2L2-S were fully characterized by various spectroscopic techniques and the solid-state structure of H2L1-S was determined via single-crystal X-ray diffraction. The high sensitivity and selectivity of the probes for Hg2+ were achieved by the Hg2+ promoted desulfurization reactions utilizing the high thiophilic nature of mercury and was monitored by UV–vis spectroscopy. Most interestingly the desulfurized product was isolated and characterized by ESI-MS and single crystal X-ray diffraction. The probes H2L1-S and H2L2-S were found to be highly selective towards acetate ion (AcO−) in fluorescence channel. These probes showed a distinct fluorescence enhancement only in the presence of AcO− at 493 nm due to the inhibition of photo induced electron transfer (PET). Finally, the cytotoxicity study was carried out for biological application. The probe showed minimum cytotoxicity and was suitable for intracellular acetate ion imaging.
Original language | English |
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Pages (from-to) | 119-130 |
Number of pages | 12 |
Journal | Inorganica Chimica Acta |
Volume | 492 |
DOIs | |
State | Published - 24 Jun 2019 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019 Elsevier B.V.
Funding
We thank Department of Science and Technology (DST) SERB ( SB/FT/CS/115/2012 ) for the financial assistance and Sophisticated Analytical and Instrumentation Facility (SAIF), North Eastern Hill University for NMR and MS data. S.P., B.S and S.K.S. thank North Eastern Hill University, CSIR (SRF) and UGC respectively for their research fellowship. Mr. D. Koner, Dept. of Zoology, NEHU is gratefully acknowledged for his help in cell imaging study. We thank Department of Science and Technology (DST) SERB (SB/FT/CS/115/2012) for the financial assistance and Sophisticated Analytical and Instrumentation Facility (SAIF), North Eastern Hill University for NMR and MS data. S.P. B.S and S.K.S. thank North Eastern Hill University, CSIR (SRF) and UGC respectively for their research fellowship. Mr. D. Koner, Dept. of Zoology, NEHU is gratefully acknowledged for his help in cell imaging study.
Funders | Funder number |
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Department of Science and Technology | |
North Eastern Hill University | |
Council of Scientific and Industrial Research, India | |
University Grants Committee | |
Science and Engineering Research Board | SB/FT/CS/115/2012 |
Department of Science and Technology |
Keywords
- AcO detection
- Bifunctional probe
- Bioimaging
- Hg detection
- Thio urea