Single cell transcriptomics: Methods and applications

Itamar Kanter, Tomer Kalisky

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Traditionally, gene expression measurements were performed on "bulk" samples containing populations of thousands of cells. Recent advances in genomic technology have made it possible to measure gene expression in hundreds of individual cells at a time. As a result, cellular properties that were previously masked in "bulk" measurements can now be observed directly. In this review we will survey emerging technologies for single cell transcriptomics, and describe how they are used to study complex disease such as cancer, as well as other biological phenomena such as tissue regeneration, embryonic development, and immune response.

Original languageEnglish
Article number53
JournalFrontiers in Oncology
Volume5
Issue numberFEB
DOIs
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2015 Kanter and Kalisky.

Keywords

  • FISH
  • Gene expression
  • RNA sequencing
  • Single cell
  • qPCR

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