Single-cell RNA sequencing for the study of lupus nephritis

Evan Der, Hemant Suryawanshi, Jill Buyon, Thomas Tuschl, Chaim Putterman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Single-cell RNA sequencing (scRNA-seq) has recently undergone rapid advances in the development of this technology, leading to high throughput and accelerating discovery in many biological systems and diseases. The single-cell resolution of the technique allows for the investigation of heterogeneity in cell populations, and the pinpointing of pathological populations contributing to disease. Here we review the development of scRNA-seq technology and the analysis that has evolved with the ever-increasing throughput. Finally, we highlight recent applications of scRNA-seq to understand the molecular pathogenesis of lupus and lupus nephritis.

Original languageEnglish
Article numbere000329
JournalLupus Science and Medicine
Issue number1
StatePublished - 1 Jun 2019
Externally publishedYes

Bibliographical note

Funding Information:
Funding Funding was provided through grants from the National Institutes of Health (UH2-AR067676, UH2-AR067677, UH2-AR067679, UH2-AR067681, UH2-AR067685, UH2-AR067688, UH2-AR067689, UH2-AR067690, UH2-AR067691, UH2-AR067694, and UM2-AR067678). Competing interests None declared. Patient consent for publication Not required. Provenance and peer review Commissioned; externally peer reviewed. open access This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:

Publisher Copyright:
© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.


  • inflammation
  • lupus nephritis
  • systemic lupus erythematosus


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