Single-Cell Profiling of Sarcomas from Archival Tissue Reveals Programs Associated with Resistance to Immune Checkpoint Blockade

Keyphrases

• Sarcoma 100%
• Single-cell Profiling 100%
• Archival Tissue 100%
• Immune Checkpoint Blockade 100%
• Cancer Cells 40%
• Transcriptome 20%
• Diverse Groups 20%
• Cancer Treatment 20%
• Tumor-infiltrating Lymphocytes 20%
• CD8+ T Cells 20%
• Diversity Loss 20%
• Current Therapies 20%
• Whole-genome Sequence Data 20%
• High-quality Data 20%
• Drug Response 20%
• Genetic Diversity 20%
• Therapy Resistance 20%
• Clonal Expansion 20%
• Rare Tumors 20%
• Frozen Tissue 20%
• Molecular Profiling 20%
• Cell-intrinsic 20%
• Cell Tumor 20%
• Multimodal Single-cell 20%
• Unbiased Analysis 20%
• Tissue Profiling 20%
• Intimal Sarcoma 20%
• Undifferentiated Pleomorphic Sarcoma 20%
• Tumor Ecosystem 20%
• Single-cell Genomics 20%
• Single-cell RNA Sequencing (scRNA-seq) 20%
• Tumor Microenvironmental 20%
• Profiling Methods 20%

Medicine and Dentistry

• Immune Checkpoint Blockade 100%
• Connective Tissue Cancer 100%
• Neoplasm 50%
• Cancer Cell 33%
• Cancer 33%
• Genetics 33%
• RNA Sequence 16%
• Cytotoxic T-Cell 16%
• T Lymphocyte 16%
• Drug Response 16%
• Therapy Resistance 16%
• Rare Tumor 16%
• Molecular Profiling 16%
• Transcriptome 16%
• Whole Genome Sequencing 16%

Biochemistry, Genetics and Molecular Biology

• Immune Checkpoints 100%
• Cancer Cell 40%
• T Cell 40%
• Genomics 40%
• RNA Sequence 20%
• Drug Response 20%
• Whole Genome Sequencing 20%
• CD8 20%
• Transcriptome 20%