Simultaneously multiparametric spectroscopic monitoring of tissue viability in the brain and small intestine

Michael Tolmasov, Efrat Barbiro-Michaely, Avraham Mayevsky

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations


Under body O2 imbalance, the Autonomic Nervous System is responsible for redistribution of blood flow with preference to the most vital organs (brain, heart), while the less vital organs (intestine, GI tract) are hypoperfused. The aim of this study was to develop and use an animal model for real time monitoring of tissue viability in the brain, and the small intestine, under various levels of oxygen and blood supply. Male Wistar rats were anesthetized, the brain cortex and intestinal serosa were exposed and connected by optical fibers to the Multi-Site Multi-Parametric (MSMP) monitoring system. Tissue blood flow (TBF) and mitochondrial NADH redox state were monitored simultaneously in the two organs. The rats were subjected to short anoxia, 20 minutes hypoxia or epinephrine (2& 8μg/kg I.V.). Under oxygen deficiency, cerebral blood flow (CBF) was elevated, whereas intestinal TBF was reduced. Mitochondrial NADH was significantly elevated in both organs. Systemic injection of Adrenaline showed a dose-depended increase in systemic blood pressure and CBF response whereas, intestinal TBF similarly decreased in both doses. In addition, NADH was elevated (reduced form) in the intestine whereas oxidation was observed in the brain. In conclusion, our preliminary results may imply the ability of using of the MSMP for monitoring non-vital organs in order to detect early changes in the balance between oxygen supply and demand in the body.

Original languageEnglish
Title of host publicationOptical Tomography and Spectroscopy of Tissue VII
StatePublished - 2007
EventOptical Tomography and Spectroscopy of Tissue VII - San Jose, CA, United States
Duration: 21 Jan 200724 Jan 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptical Tomography and Spectroscopy of Tissue VII
Country/TerritoryUnited States
CitySan Jose, CA


  • Adrenaline
  • Anoxia
  • Brain
  • Hypoxia
  • Microcirculatory blood flow
  • Mitochondrial NADH
  • Small intestine


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