Simultaneous panic and depressive disorders: Clinical and sleep EEG correlates

Leon Grunhaus, David Rabin, Yossi Harel, John F. Greden, Michael Feinberg, Rita Hermann

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Panic and depressive symptoms occur simulataneously in many depressed patients. To study the frequency of this association and to determine whether patients with simultaneous panic and major depression differed from those with only major depressive disorder (MDD) in clinical features and in sleep electroencephalographic (EEG) variables, we evaluated a total sample of 336 patients with MDD. Fifty-eight (17%) had both panic and MDD; 50 had complete data and were matched for age and severity of illness with other patients having only MDD. Patients with simultaneous panic and depression had significantly higher ratings for psychic and somatic anxiety, and rapid eye movement (REM) latencies approximating normal values. Patients with only MDD (without panic disorder) rated significantly higher in guilt feelings and had shorter REM latencies. Our results suggest that the simultaneous occurence of panic and depression is relatively frequent, is accompanied by differences in sleep EEG variables, and may have implications for treatment.

Original languageEnglish
Pages (from-to)251-259
Number of pages9
JournalPsychiatry Research
Issue number4
StatePublished - Apr 1986
Externally publishedYes

Bibliographical note

Funding Information:
The research reported was supported in part by Public Health Service Grant MH-28294; by the Mental Health Research Institute, University of Michigan, Ann Arbor; and by the State of Michigan Department of Mental Health, Lansing.


  • Major depressive disorder
  • panic disorder
  • sleep electroencephalographic


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