Simulation of morphologically structured photo-thermal neural stimulation

Y. Weissler, N. Farah, S. Shoham

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective. Rational design of next-generation techniques for photo-thermal excitation requires the development of tools capable of modeling the effects of spatially- and temporally-dependent temperature distribution on cellular neuronal structures. Approach. We present a new computer simulation tool for predicting the effects of arbitrary spatiotemporally-structured photo-thermal stimulation on 3D, morphologically realistic neurons. The new simulation tool is based on interfacing two generic platforms, NEURON and MATLAB and is therefore suited for capturing different kinds of stimuli and neural models. Main results. Simulation results are validated using photo-absorber induced neuro-thermal stimulation (PAINTS) empirical results, and advanced features are explored. Significance. The new simulation tool could have an important role in understanding and investigating complex optical stimulation at the single-cell and network levels.

Original languageEnglish
Article number055001
JournalJournal of Neural Engineering
Volume14
Issue number5
DOIs
StatePublished - Oct 2017

Bibliographical note

Publisher Copyright:
© 2017 IOP Publishing Ltd.

Keywords

  • MATLAB-NEURON interface
  • computer generated holography
  • computer simulation
  • photo-thermal stimulation
  • stimulation pattern optimization

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