TY - JOUR
T1 - Silver and gold doped hydroxyapatite nanocomposites for enhanced bone regeneration
AU - Kumar, Vijay Bhooshan
AU - Khajuria, Deepak Kumar
AU - Karasik, David
AU - Gedanken, Aharon
N1 - Publisher Copyright:
© 2019 IOP Publishing Ltd.
PY - 2019/7/8
Y1 - 2019/7/8
N2 - We report the osteogenic potential of silver (Ag), gold (Au), or silver-gold doped hydroxyapatite nanoparticles (Ag-Au-HA) in zebrafish (ZF) jawbone regeneration (JBR) model. The hydroxyapatite (HA, Ca10(PO4)6(OH)2), Ag-HA, Au-HA, and Ag-Au-HA nanomaterials were synthesized by the co-precipitation procedure. The surface structures of Ag-HA, Au-HA, HA, and Ag-Au-HA were analysed by scanning electron microscopy, transmission-electron microscopy (TEM), X-ray diffraction, Fourier transform infrared (FTIR), UV-vis, energy dispersive X-ray spectroscopy (EDS), elemental mapping, and laser fluorescent spectroscopy. The TEM and EDS analysis confirmed that the Ag and Au are associated with the surface of HA nanoparticle. The chemical structure of HA, Ag-HA, Au-HA, and Ag-Au-HA nanoparticles was validated by FTIR and EDS analysis. We observed that Ag and Au are associated with HA nanoparticles by electrostatic, wander wall, and electrostatic and H-bonding interaction. The effect of Ag-HA, Au-HA, and Ag-Au-HA nanoparticles on bone regeneration was confirmed by ZF JBR model. The significant growth of ZF bone regeneration was observed in Ag-Au-HA nanoparticles as compared with HA, Ag-HA, and Au-HA nanoparticles. These results indicating a therapeutic potential of Ag-Au-HA compositions suggest these nanomaterials would be excellent for bone regeneration and fracture healing.
AB - We report the osteogenic potential of silver (Ag), gold (Au), or silver-gold doped hydroxyapatite nanoparticles (Ag-Au-HA) in zebrafish (ZF) jawbone regeneration (JBR) model. The hydroxyapatite (HA, Ca10(PO4)6(OH)2), Ag-HA, Au-HA, and Ag-Au-HA nanomaterials were synthesized by the co-precipitation procedure. The surface structures of Ag-HA, Au-HA, HA, and Ag-Au-HA were analysed by scanning electron microscopy, transmission-electron microscopy (TEM), X-ray diffraction, Fourier transform infrared (FTIR), UV-vis, energy dispersive X-ray spectroscopy (EDS), elemental mapping, and laser fluorescent spectroscopy. The TEM and EDS analysis confirmed that the Ag and Au are associated with the surface of HA nanoparticle. The chemical structure of HA, Ag-HA, Au-HA, and Ag-Au-HA nanoparticles was validated by FTIR and EDS analysis. We observed that Ag and Au are associated with HA nanoparticles by electrostatic, wander wall, and electrostatic and H-bonding interaction. The effect of Ag-HA, Au-HA, and Ag-Au-HA nanoparticles on bone regeneration was confirmed by ZF JBR model. The significant growth of ZF bone regeneration was observed in Ag-Au-HA nanoparticles as compared with HA, Ag-HA, and Au-HA nanoparticles. These results indicating a therapeutic potential of Ag-Au-HA compositions suggest these nanomaterials would be excellent for bone regeneration and fracture healing.
KW - bone regenaration
KW - hydroxyapatite
KW - nanoparticles
KW - silver
KW - zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85069296848&partnerID=8YFLogxK
U2 - 10.1088/1748-605x/ab28e4
DO - 10.1088/1748-605x/ab28e4
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C2 - 31185462
AN - SCOPUS:85069296848
SN - 1748-6041
VL - 14
JO - Biomedical Materials (Bristol)
JF - Biomedical Materials (Bristol)
IS - 5
M1 - 055002
ER -