Significant anisotropic neuronal refractory period plasticity

Roni Vardi, Yael Tugendhaft, Shira Sardi, Ido Kanter

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Refractory periods are an unavoidable feature of excitable elements, resulting in necessary time-lags for re-excitation. Herein, we measure neuronal absolute refractory periods (ARPs) in synaptic blocked neuronal cultures. In so doing, we show that their duration can be significantly extended by dozens of milliseconds using preceding evoked spikes generated by extracellular stimulations. The ARP increases with the frequency of preceding stimulations, and saturates at the intermittent phase of the neuronal response latency, where a short relative refractory period might appear. Nevertheless, preceding stimulations via a different extracellular route does not affect the ARP. It is also found to be independent of preceding intracellular stimulations. All these features strongly suggest that the anisotropic ARPs originate in neuronal dendrites. The results demonstrate the fast and significant plasticity of the neuronal ARP, depending on the firing activity of its connecting neurons, which is expected to affect network dynamics.

Original languageEnglish
Article number60007
Issue number6
StatePublished - Jun 2021

Bibliographical note

Publisher Copyright:
© Copyright2021 EPLA.


Dive into the research topics of 'Significant anisotropic neuronal refractory period plasticity'. Together they form a unique fingerprint.

Cite this