Short-term sleep deprivation in mice induces B cell migration to the brain compartment

Ben Korin, Shimrit Avraham, Hilla Azulay-Debby, Dorit Farfara, Fahed Hakim, Asya Rolls

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Increasing evidence highlight the involvement of immune cells in brain activity and its dysfunction. The brain's immune compartment is a dynamic ensemble of cells that can fluctuate even in naive animals. However, the dynamics and factors that can affect the composition of immune cells in the naive brain are largely unknown. Here, we examined whether acute sleep deprivation can affect the brain's immune compartment (parenchyma, meninges, and choroid plexus). Using high-dimensional mass cytometry analysis, we broadly characterized the effects of short-term sleep deprivation on the immune composition in the mouse brain. We found that after 6 h of sleep deprivation, there was a significant increase in the abundance of B cells in the brain compartment. This effect can be accounted for, at least in part, by the elevated expression of the migration-related receptor, CXCR5, on B cells and its ligand, cxcl13, in the meninges following sleep deprivation. Thus, our study reveals that short-term sleep deprivation affects the brain's immune compartment, offering a new insight into how sleep disorders can affect brain function and potentially contribute to neurodegeneration and neuroinflammation.

Original languageEnglish
Article numberzsz222
JournalSleep
Volume43
Issue number2
DOIs
StatePublished - 13 Feb 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Sleep Research Society 2019. Published by Oxford University Press [on behalf of the Sleep Research Society].

Keywords

  • B cells
  • CXCR5
  • brain compartment
  • cxcl13
  • immune cells
  • immunology
  • neuroimmunology
  • sleep deprivation

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