Shedding light on mitochondrial function by real time monitoring of NADH fluorescence: II: Human studies

Avraham Mayevsky, Efrat Barbiro-Michaely

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Monitoring the mitochondrial function, alone or together with microcirculatory blood flow, volume and hemoglobin oxygenation in patients, is very rare. The integrity of microcirculation and mitochondrial activity is a key factor in keeping normal cellular activities. Many pathological conditions in patients are directly or indirectly related to dysfunction of the mitochondria. Evaluation of mitochondrial activity by measuring the autofluorescence of NADH has been the most practical approach since the 1950s. This review, which accompanies part I, presents the principles and technological aspects of various devices used in order to monitor mitochondrial NADH redox state and tissue viability in patients. In part I, the detailed technological aspects of NADH monitoring were described. Typical results accumulated in our studies since the mid-1990s are presented as well. We were able to apply the fiber optic based NADH fluorometry to several organs monitored in vivo in patients under various pathophysiological conditions.

Original languageEnglish
Pages (from-to)125-145
Number of pages21
JournalJournal of Clinical Monitoring and Computing
Volume27
Issue number2
DOIs
StatePublished - Apr 2013

Keywords

  • Brain metabolism
  • Cellular energy metabolism
  • In vivo monitoring
  • Intracellular NADH autofluorescence
  • Patients monitoring
  • Tissue oxygen balance

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