Severe pulmonary hypertension associated with emphysema: A new phenotype?

Yochai Adir, Robert Shachner, Offer Amir, Marc Humbert

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Mild to moderate precapillary pulmonary hypertension (PH) is a common complication of COPD and has typically been related to severe airflow limitation associated with chronic hypoxemia. Previous studies focusing specifically on patients with emphysema found that worsening PH was associated with progression of airflow obstruction. In the present report, we describe a new phenotype of COPD with severe precapillary PH in patients presenting with progressive dyspnea, normal spirometry, severely reduced diffusion capacity of the lung for carbon monoxide, and highresolution CT scans of the chest showing diffuse centrilobular emphysema.

Original languageEnglish
Pages (from-to)1654-1658
Number of pages5
Issue number6
StatePublished - Dec 2012
Externally publishedYes


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