Severe ovarian hyperstimulation syndrome: A reevaluated therapeutic approach

R. Borenstein, U. Elhalah, B. Lunenfeld, Z. S. Schwartz

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

During the 10 years 1978 to 1987, 33 patients were hospitalized because of moderate and severe ovarian hyperstimulation syndrome (OHSS) in 39 treatment cycles. Twenty-five treatment cycles ended in moderate OHSS (group A), 7 had severe OHSS without a significant amount of ascites (group B1), and 7 had severe OHSS with ascites (group B2). Groups A and B1 received intravascular volume expander, electrolytes replacement, and indomethacin up to 300 mg/day. The patients in group B2 had significant clinical and biochemical improvement after abdominal paracentesis. Urinary output and creatinine clearance improved significantly, and a decrease in hematocrit, blood osmolarity, and weight reduction were achieved. A strategy for treatment of OHSS based on consecutive ultrasonographic examination, clinical and biochemical evaluation, and abdominal paracentesis in severe OHSS with clinically significant ascites is suggested.

Original languageEnglish
Pages (from-to)791-795
Number of pages5
JournalFertility and Sterility
Volume51
Issue number5
DOIs
StatePublished - May 1989
Externally publishedYes

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