Set and setting in microdosing: an oft-overlooked principle

Ido Hartogsohn, Rotem Petranker

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Rationale: The use of psychedelics for medical and recreational purposes is rising. Contextual factors such as expectancy, intention, and sensory and social environment (set and setting) are widely recognized as moderating the effects of these substances. Nevertheless, clinical trials of microdosing — the ingestion of small, sub-hallucinogenicdoses of psychedelics — rarely report their set and setting. This fact suggests that such factors are not considered important in the context of microdosing. Objective: This paper challenges this assumption and makes the case for the crucial relevance of set and setting in microdosing practice. Building on set and setting theory and placebo theory, we explain why set and setting are of crucial importance in the case of microdosing. Results: This reasoning helps elucidate the role of set and setting in determining the outcomes of microdosing and helps explain some of the contradictory results that have emerged in microdosing research in recent years. Conclusion: Set and setting are important constructs to be considered especially in the context of microdosing psychedelics. By reporting set and setting, the results of microdosing research can be made more reliable and consistent.

Original languageEnglish
Pages (from-to)3771-3777
Number of pages7
Issue number12
StatePublished - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.


  • LSD
  • Microdosing
  • Psilocybin
  • Psychedelics
  • Set and setting


Dive into the research topics of 'Set and setting in microdosing: an oft-overlooked principle'. Together they form a unique fingerprint.

Cite this