Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients

Offer Amir; Hagar Paz; Ori Rogowski; Marina Barshai; Moran Sagiv; Sergei Shnizer; Abraham Z. Reznick; Ruthie E. Amir

doi:10.1002/clc.20317

Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients

Offer Amir, Hagar Paz, Ori Rogowski, Marina Barshai, Moran Sagiv, Sergei Shnizer, Abraham Z. Reznick, Ruthie E. Amir

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Abstract

Background: Serum oxidative stress (OS) level has an important role in the inflammatory process of heart failure. Hypothesis: The study was designed to analyze serum OS levels in chronic heart failure (HF) patients and to examine the relation between OS levels and other clinical and prognostic parameters of HF. Methods: We studied 82 consecutive chronic symptomatic HF patients with systolic LV dysfunction (ejection fraction < 45%). The serum OS level was determined using thermochemiluminescence assay. We compared the serum OS levels with patients' clinical and prognostic parameters. Results: Higher serum OS levels were associated with higher New York Heart Association class (P = .01), worse renal function (serum urea, creatinine, and creatinine clearance) (P<.001) and higher serum levels of hs-C-reactive protein and N-terminal pro brain natriuretic peptide (P = .001, P<.001, respectively). Conclusions: In chronic systolic HF patients, high serum OS levels correlate with advanced disease and known markers of poor prognosis.

Original language	English
Pages (from-to)	199-203
Number of pages	5
Journal	Clinical Cardiology
Volume	32
Issue number	4
DOIs	https://doi.org/10.1002/clc.20317
State	Published - Apr 2009
Externally published	Yes

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title = "Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients",

abstract = "Background: Serum oxidative stress (OS) level has an important role in the inflammatory process of heart failure. Hypothesis: The study was designed to analyze serum OS levels in chronic heart failure (HF) patients and to examine the relation between OS levels and other clinical and prognostic parameters of HF. Methods: We studied 82 consecutive chronic symptomatic HF patients with systolic LV dysfunction (ejection fraction < 45%). The serum OS level was determined using thermochemiluminescence assay. We compared the serum OS levels with patients' clinical and prognostic parameters. Results: Higher serum OS levels were associated with higher New York Heart Association class (P = .01), worse renal function (serum urea, creatinine, and creatinine clearance) (P<.001) and higher serum levels of hs-C-reactive protein and N-terminal pro brain natriuretic peptide (P = .001, P<.001, respectively). Conclusions: In chronic systolic HF patients, high serum OS levels correlate with advanced disease and known markers of poor prognosis.",

author = "Offer Amir and Hagar Paz and Ori Rogowski and Marina Barshai and Moran Sagiv and Sergei Shnizer and Reznick, {Abraham Z.} and Amir, {Ruthie E.}",

year = "2009",

month = apr,

doi = "10.1002/clc.20317",

language = "אנגלית",

volume = "32",

pages = "199--203",

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T1 - Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients

AU - Amir, Offer

AU - Paz, Hagar

AU - Rogowski, Ori

AU - Barshai, Marina

AU - Sagiv, Moran

AU - Shnizer, Sergei

AU - Reznick, Abraham Z.

AU - Amir, Ruthie E.

PY - 2009/4

Y1 - 2009/4

N2 - Background: Serum oxidative stress (OS) level has an important role in the inflammatory process of heart failure. Hypothesis: The study was designed to analyze serum OS levels in chronic heart failure (HF) patients and to examine the relation between OS levels and other clinical and prognostic parameters of HF. Methods: We studied 82 consecutive chronic symptomatic HF patients with systolic LV dysfunction (ejection fraction < 45%). The serum OS level was determined using thermochemiluminescence assay. We compared the serum OS levels with patients' clinical and prognostic parameters. Results: Higher serum OS levels were associated with higher New York Heart Association class (P = .01), worse renal function (serum urea, creatinine, and creatinine clearance) (P<.001) and higher serum levels of hs-C-reactive protein and N-terminal pro brain natriuretic peptide (P = .001, P<.001, respectively). Conclusions: In chronic systolic HF patients, high serum OS levels correlate with advanced disease and known markers of poor prognosis.

AB - Background: Serum oxidative stress (OS) level has an important role in the inflammatory process of heart failure. Hypothesis: The study was designed to analyze serum OS levels in chronic heart failure (HF) patients and to examine the relation between OS levels and other clinical and prognostic parameters of HF. Methods: We studied 82 consecutive chronic symptomatic HF patients with systolic LV dysfunction (ejection fraction < 45%). The serum OS level was determined using thermochemiluminescence assay. We compared the serum OS levels with patients' clinical and prognostic parameters. Results: Higher serum OS levels were associated with higher New York Heart Association class (P = .01), worse renal function (serum urea, creatinine, and creatinine clearance) (P<.001) and higher serum levels of hs-C-reactive protein and N-terminal pro brain natriuretic peptide (P = .001, P<.001, respectively). Conclusions: In chronic systolic HF patients, high serum OS levels correlate with advanced disease and known markers of poor prognosis.

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Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients

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